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- W2025578509 abstract "Prostaglandin F 2 α (PGF 2 α ) is a key factor in the triggering of the regression of the corpus luteum (CL). Furthermore, it has been reported that Slit/Robo signaling is involved in the regulation of luteolysis. However, the interactions between PGF 2 α and Slit/Robo in the progression of luteolysis remain to be established. This study was designed to determine whether luteolysis is regulated by the interactions of PGF 2 α and Slit/Robo in the mouse CL. Real-time PCR and immunohistochemistry results showed that Slit2 and its receptor Robo1 are highly and specifically co-expressed in the mouse CL. Functional studies showed that Slit/Robo participates in mouse luteolysis by enhancing cell apoptosis and upregulating caspase3 expression. Both in vitro and in vivo studies showed that PGF 2 α significantly increases the expression of Slit2 and Robo1 during luteolysis through protein kinase C-dependent ERK1/2 and P38 MAPK signaling pathways, whereas an inhibitor of Slit/Robo signaling significantly decreases the stimulating effect of PGF 2 α on luteolysis. These findings indicate that Slit/Robo signaling plays important roles in PGF 2 α -induced luteolysis by mediating the PGF 2 α signaling pathway in the CL." @default.
- W2025578509 created "2016-06-24" @default.
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- W2025578509 date "2013-06-28" @default.
- W2025578509 modified "2023-10-16" @default.
- W2025578509 title "Prostaglandin F2 α upregulates Slit/Robo expression in mouse corpus luteum during luteolysis" @default.
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- W2025578509 doi "https://doi.org/10.1530/joe-13-0088" @default.
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