Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025595434> ?p ?o ?g. }
- W2025595434 endingPage "1260" @default.
- W2025595434 startingPage "1244" @default.
- W2025595434 abstract "Amyloids are highly ordered cross-β sheet protein aggregates associated with many diseases including Alzheimer's disease, but also with biological functions such as hormone storage. The cross-β sheet entity comprising an indefinitely repeating intermolecular β sheet motif is unique among protein folds. It grows by recruitment of the corresponding amyloid protein, while its repetitiveness can translate what would be a nonspecific activity as monomer into a potent one through cooperativity. Furthermore, the one-dimensional crystal-like repeat in the amyloid provides a structural framework for polymorphisms. This review summarizes the recent high-resolution structural studies of amyloid fibrils in light of their biological activities. We discuss how the unique properties of amyloids gives rise to many activities and further speculate about currently undocumented biological roles for the amyloid entity. In particular, we propose that amyloids could have existed in a prebiotic world, and may have been the first functional protein fold in living cells." @default.
- W2025595434 created "2016-06-24" @default.
- W2025595434 creator A5011793639 @default.
- W2025595434 creator A5084176856 @default.
- W2025595434 date "2010-10-01" @default.
- W2025595434 modified "2023-10-16" @default.
- W2025595434 title "Biology of Amyloid: Structure, Function, and Regulation" @default.
- W2025595434 cites W133512539 @default.
- W2025595434 cites W1489708565 @default.
- W2025595434 cites W1503622815 @default.
- W2025595434 cites W1522008919 @default.
- W2025595434 cites W1544926311 @default.
- W2025595434 cites W1548745754 @default.
- W2025595434 cites W1595368494 @default.
- W2025595434 cites W1772692214 @default.
- W2025595434 cites W1964976698 @default.
- W2025595434 cites W1968516843 @default.
- W2025595434 cites W1969553345 @default.
- W2025595434 cites W1971850620 @default.
- W2025595434 cites W1973173577 @default.
- W2025595434 cites W1974187431 @default.
- W2025595434 cites W1976103641 @default.
- W2025595434 cites W1976201852 @default.
- W2025595434 cites W1979138426 @default.
- W2025595434 cites W1979575360 @default.
- W2025595434 cites W1980906872 @default.
- W2025595434 cites W1982960377 @default.
- W2025595434 cites W1984569087 @default.
- W2025595434 cites W1987686455 @default.
- W2025595434 cites W1989172027 @default.
- W2025595434 cites W1990592765 @default.
- W2025595434 cites W1993773159 @default.
- W2025595434 cites W1995496955 @default.
- W2025595434 cites W1996837502 @default.
- W2025595434 cites W1997973599 @default.
- W2025595434 cites W2000204824 @default.
- W2025595434 cites W2001598411 @default.
- W2025595434 cites W2003258297 @default.
- W2025595434 cites W2004098528 @default.
- W2025595434 cites W2004333317 @default.
- W2025595434 cites W2006219887 @default.
- W2025595434 cites W2006303650 @default.
- W2025595434 cites W2006943139 @default.
- W2025595434 cites W2009158644 @default.
- W2025595434 cites W2009207248 @default.
- W2025595434 cites W2009845005 @default.
- W2025595434 cites W2010499900 @default.
- W2025595434 cites W2010745676 @default.
- W2025595434 cites W2012920767 @default.
- W2025595434 cites W2013679718 @default.
- W2025595434 cites W2014272598 @default.
- W2025595434 cites W2014297210 @default.
- W2025595434 cites W2015329538 @default.
- W2025595434 cites W2015444119 @default.
- W2025595434 cites W2015675204 @default.
- W2025595434 cites W2015889028 @default.
- W2025595434 cites W2016417523 @default.
- W2025595434 cites W2017701206 @default.
- W2025595434 cites W2021785060 @default.
- W2025595434 cites W2024895112 @default.
- W2025595434 cites W2025399871 @default.
- W2025595434 cites W2027250745 @default.
- W2025595434 cites W2027839322 @default.
- W2025595434 cites W2029314989 @default.
- W2025595434 cites W2030072508 @default.
- W2025595434 cites W2030310183 @default.
- W2025595434 cites W2030420318 @default.
- W2025595434 cites W2031007679 @default.
- W2025595434 cites W2032469042 @default.
- W2025595434 cites W2034589999 @default.
- W2025595434 cites W2036254230 @default.
- W2025595434 cites W2038673804 @default.
- W2025595434 cites W2039329450 @default.
- W2025595434 cites W2042978244 @default.
- W2025595434 cites W2045820581 @default.
- W2025595434 cites W2046093999 @default.
- W2025595434 cites W2046847750 @default.
- W2025595434 cites W2046961612 @default.
- W2025595434 cites W2054249920 @default.
- W2025595434 cites W2055378374 @default.
- W2025595434 cites W2056046302 @default.
- W2025595434 cites W2057293794 @default.
- W2025595434 cites W2060393626 @default.
- W2025595434 cites W2060983898 @default.
- W2025595434 cites W2063423234 @default.
- W2025595434 cites W2064931700 @default.
- W2025595434 cites W2065123804 @default.
- W2025595434 cites W2065259975 @default.
- W2025595434 cites W2067258774 @default.
- W2025595434 cites W2067362253 @default.
- W2025595434 cites W2067540111 @default.
- W2025595434 cites W2068925084 @default.
- W2025595434 cites W2072613948 @default.
- W2025595434 cites W2072984130 @default.
- W2025595434 cites W2073893553 @default.
- W2025595434 cites W2075481535 @default.
- W2025595434 cites W2075813074 @default.
- W2025595434 cites W2076892004 @default.