FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025597909> ?p ?o ?g. }

• W2025597909 endingPage "426" @default.
• W2025597909 startingPage "416" @default.
• W2025597909 abstract "The anti-inflammatory and anti-nociceptive effects and the molecular mechanisms of JCICM-6, a purified extract derived from an anti-arthritic Chinese herbal formula composed of Caulis Sinomenii, Aconiti laterralis Preparata, Rhizoma Curcumae longae, Radix Paeoniae albae, and Cortex Moutan, were examined for the first time. JCICM-6 was prepared using pharmaceutical extraction technology, purified by Amberlite XAD-7HP polymeric resin. Pharmacologically, in carrageenan-induced edema and carrageenan-evoked thermal hyperalgesia in paws of rats, the oral administration of JCICM-6 at dosages of 0.4, 0.8, and 1.6 g/kg demonstrated significant inhibition with a dose-dependent manner. Mechanistic studies showed that JCICM-6 effectively decreased the production of the pro-inflammatory cytokines of IL-6 and IL-1β and expression of COX-2 and iNOS proteins, and simultaneously elevated the level of anti-inflammatory cytokine IL-4 in the carrageenan-injected rat paw tissues and exudates. The positive reference drug, indomethacin at a dosage of 10 mg/kg, demonstrated inhibitory potency in both rat models, but it could not augment the production of IL-4, indicating JCICM-6 and indomethacin might possess different pharmacological properties and molecular mechanisms although both have anti-inflammatory and analgesic effects in rats. These results suggest that JCICM-6 would be a valuable candidate for further investigation as a new anti-arthritic drug." @default.
• W2025597909 created "2016-06-24" @default.
• W2025597909 creator A5007589833 @default.
• W2025597909 creator A5021798810 @default.
• W2025597909 creator A5034527222 @default.
• W2025597909 creator A5047044100 @default.
• W2025597909 creator A5075759328 @default.
• W2025597909 creator A5086342255 @default.
• W2025597909 date "2008-06-01" @default.
• W2025597909 modified "2023-09-22" @default.
• W2025597909 title "Anti-inflammatory and analgesic effects and molecular mechanisms of JCICM-6, a purified extract derived from an anti-arthritic Chinese herbal formula" @default.
• W2025597909 cites W1500856190 @default.
• W2025597909 cites W1527206559 @default.
• W2025597909 cites W1560571961 @default.
• W2025597909 cites W1599995295 @default.
• W2025597909 cites W1640867939 @default.
• W2025597909 cites W1758796768 @default.
• W2025597909 cites W1975064294 @default.
• W2025597909 cites W1981819970 @default.
• W2025597909 cites W1984632338 @default.
• W2025597909 cites W1985018911 @default.
• W2025597909 cites W1985875573 @default.
• W2025597909 cites W1987252817 @default.
• W2025597909 cites W1992625772 @default.
• W2025597909 cites W1997510003 @default.
• W2025597909 cites W2014007136 @default.
• W2025597909 cites W2033417908 @default.
• W2025597909 cites W2040286969 @default.
• W2025597909 cites W2040701984 @default.
• W2025597909 cites W2046399807 @default.
• W2025597909 cites W2054786784 @default.
• W2025597909 cites W2065054671 @default.
• W2025597909 cites W2066649179 @default.
• W2025597909 cites W2072243796 @default.
• W2025597909 cites W2072259978 @default.
• W2025597909 cites W2072696221 @default.
• W2025597909 cites W2078259729 @default.
• W2025597909 cites W2084990572 @default.
• W2025597909 cites W2089747387 @default.
• W2025597909 cites W2090703365 @default.
• W2025597909 cites W2095334838 @default.
• W2025597909 cites W2096720114 @default.
• W2025597909 cites W2102368544 @default.
• W2025597909 cites W2110285935 @default.
• W2025597909 cites W2118781231 @default.
• W2025597909 cites W2123274778 @default.
• W2025597909 cites W2132579331 @default.
• W2025597909 cites W2141399945 @default.
• W2025597909 cites W2149026148 @default.
• W2025597909 cites W2163756514 @default.
• W2025597909 cites W3023923910 @default.
• W2025597909 doi "https://doi.org/10.1016/j.phymed.2008.02.008" @default.
• W2025597909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18424100" @default.
• W2025597909 hasPublicationYear "2008" @default.
• W2025597909 type Work @default.
• W2025597909 sameAs 2025597909 @default.
• W2025597909 citedByCount "18" @default.
• W2025597909 countsByYear W20255979092012 @default.
• W2025597909 countsByYear W20255979092013 @default.
• W2025597909 countsByYear W20255979092015 @default.
• W2025597909 countsByYear W20255979092016 @default.
• W2025597909 countsByYear W20255979092018 @default.
• W2025597909 countsByYear W20255979092019 @default.
• W2025597909 countsByYear W20255979092020 @default.
• W2025597909 countsByYear W20255979092022 @default.
• W2025597909 crossrefType "journal-article" @default.
• W2025597909 hasAuthorship W2025597909A5007589833 @default.
• W2025597909 hasAuthorship W2025597909A5021798810 @default.
• W2025597909 hasAuthorship W2025597909A5034527222 @default.
• W2025597909 hasAuthorship W2025597909A5047044100 @default.
• W2025597909 hasAuthorship W2025597909A5075759328 @default.
• W2025597909 hasAuthorship W2025597909A5086342255 @default.
• W2025597909 hasConcept C15490471 @default.
• W2025597909 hasConcept C162156334 @default.
• W2025597909 hasConcept C170493617 @default.
• W2025597909 hasConcept C185592680 @default.
• W2025597909 hasConcept C202751555 @default.
• W2025597909 hasConcept C2779245659 @default.
• W2025597909 hasConcept C2779703632 @default.
• W2025597909 hasConcept C2780820201 @default.
• W2025597909 hasConcept C2781227287 @default.
• W2025597909 hasConcept C55493867 @default.
• W2025597909 hasConcept C556039675 @default.
• W2025597909 hasConcept C57992300 @default.
• W2025597909 hasConcept C71924100 @default.
• W2025597909 hasConcept C98274493 @default.
• W2025597909 hasConceptScore W2025597909C15490471 @default.
• W2025597909 hasConceptScore W2025597909C162156334 @default.
• W2025597909 hasConceptScore W2025597909C170493617 @default.
• W2025597909 hasConceptScore W2025597909C185592680 @default.
• W2025597909 hasConceptScore W2025597909C202751555 @default.
• W2025597909 hasConceptScore W2025597909C2779245659 @default.
• W2025597909 hasConceptScore W2025597909C2779703632 @default.
• W2025597909 hasConceptScore W2025597909C2780820201 @default.
• W2025597909 hasConceptScore W2025597909C2781227287 @default.
• W2025597909 hasConceptScore W2025597909C55493867 @default.
• W2025597909 hasConceptScore W2025597909C556039675 @default.
• W2025597909 hasConceptScore W2025597909C57992300 @default.

• next