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- W2025601894 abstract "The presence of moderate level of proanthocyanins (PAs) in the alfalfa can confer this world largest forage several desirable traits such as pasture bloat free and high protein using rate. However, it has long been an unsolved metabolic engineering issue to engineer the seed-produced PAs into leaf and stem. We characterized two transcription factors MtPAR and MtTT8 that essentially regulate the biosynthesis of PAs in seeds. We demonstrated that MtPAR activates PA biosynthetic pathway by not only up-regulating PA structural genes, but also by suppressing isoflavone biosynthesis in transgenic hairy roots. Transcriptomic and metabolomic profiling, and MtPAR binding to isoflavone synthase (IFS) promoter region all support the metabolic switch. In addition, MtTT8 is functionally characterized as a downstream regulator for PA and anthocyanin biosynthesis with transcriptomic and metabolomic tools. MtTT8 is regulated by MtPAR and MtWD40 at transcriptional level, also their proteins forma ternary complex to regulate key PA or anthocyanin biosynthetic genes. Revealing these regulatory mechanisms could facilitate our metabolic engineering of PAs to generate a pasture bloat free alfalfa variety." @default.
- W2025601894 created "2016-06-24" @default.
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- W2025601894 date "2014-07-14" @default.
- W2025601894 modified "2023-10-14" @default.
- W2025601894 title "Transcirptional regulation of proanthocyanidin biosynthesis by MTPAR and MTTT8 as well as their interaction regulatory complex" @default.
- W2025601894 doi "https://doi.org/10.1055/s-0034-1382627" @default.
- W2025601894 hasPublicationYear "2014" @default.
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