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• W2025606937 abstract "Although image-guided radiation therapy (IGRT) is widely used to determine and to correct the daily setup error, the additional interpretation for image registration should provide additional variability. We evaluated the uncertainty as to 3D image registration in IGRT. The subjects consisted of 12 consecutive patients treated with IGRT for esophageal cancer. Two radiation therapists had consensually achieved daily 3D registration between planning computed tomography (CT) and cone beam CT (CBCT). The original data sets of image registration (original: O) in all fractions but boost irradiations with isocenter alternation were selected for evaluation. There were 20 to 32 data sets in each patient: a total of 318 data sets. To assess the reproducibility of image registration, an experienced radiation therapist (observer A) reviewed the data sets and recorded geometric differences as interobserver variability. Taking into consideration the individual differences, another radiation therapist also did twice at a 1-month interval (observers B and B’). To assess interobserver and intraobserver variability in image registration, we compared O vs A, O vs B, A vs B, and B vs B’; the geometric differences were characterized by the mean values and standard deviations (SDs) along the three directions and the mean 3D vector in each patient. The variability in image registration was estimated using intraclass correlation coefficient (ICC) produced from a two-way random model, with both observers and patients being random factors. Interobserver and intraobserver variability existed in each direction; the mean 3D vectors were approximately 1 - 2 mm in all setting for patients and observers (Table). The parameters between a pair of observers were similar to those of other observer pairs in the same patient; the mean 3D vectors for 12 patients were reproducible by other observer pairs (ICC = 0.526, p < 0.001). Although IGRT can correct the setup error, the potential uncertainty exists as to the image registration. The uncertainty should be mainly derived from patients rather than observers.Scientific Abstract 3649; TableInterobserver and intraobserver variability along the 3 directions and 3D vectorParameterInterobserverIntraobserverO vs AO vs BA vs BB vs B’LRmean-0.1 to 0.9-0.1 to 1.1-0.5 to 0.4-0.2 to 0.5(SD)(0.5 to 1.3)(0.5 to 1.3)(0.5 to 1.8)(0.5 to 1.1)SImean-0.3 to 0.9-0.7 to 1.0-0.1 to 0.6-0.2 to 0.4(SD)(0.5 to 1.6)(0.5 to 1.3)(0.4 to 1.1)(0.4 to 0.7)APmean-0.5 to 0.4-1.2 to 0.0-0.2 to 1.5-0.6 to 0.4(SD)(0.5 to 1.5)(0.6 to 1.6)(0.5 to 1.7)(0.5 to 1.3)mean 3D vector0.7 to 2.11.0 to 2.20.9 to 2.20.6 to 1.5Data (mm) are ranges of parameters in 12 patientsLR = the left-right direction, SI = the superior-inferior direction, AP = the anterior-posterior direction Open table in a new tab" @default.
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• W2025606937 date "2014-09-01" @default.
• W2025606937 modified "2023-09-24" @default.
• W2025606937 title "Potential Uncertainty as to 3D Image Registration in Thoracic Image Guided Radiation Therapy" @default.
• W2025606937 doi "https://doi.org/10.1016/j.ijrobp.2014.05.2457" @default.
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