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- W2025615265 abstract "Mounting evidences support the idea that endogenous 'biometals', such as copper, iron, zinc and exogenous ones such as aluminum, can be involved as factors or cofactors in the etiopathogenesis of a variety of neurodegenerative diseases. Alzheimer's disease (AD) is a multifactorial neurodegenerative condition associated with pathological accumulation of amyloid plaques and with the appearance of deposit of neurofibrillary tangles. In AD, the process of beta-amyloid (Abeta) misfolding and plaque aggregation is greatly influenced by alterations in the homeostasis of the aforementioned metal ions. Here, we discuss the most recent evidences that associate metal ion dyshomeostasis with the development of AD. As for aluminum, a role for this ion in AD pathogenesis is still controversial. Thus, here, we also critically review new findings that argue for and against the 'aluminum hypothesis'. Finally, it is discussed how therapeutic strategies aimed at restoring metal homeostasis can delay and modify the progression of AD-related neurodegeneration." @default.
- W2025615265 created "2016-06-24" @default.
- W2025615265 creator A5000018003 @default.
- W2025615265 creator A5023148187 @default.
- W2025615265 creator A5058319971 @default.
- W2025615265 creator A5087509226 @default.
- W2025615265 date "2009-07-01" @default.
- W2025615265 modified "2023-10-18" @default.
- W2025615265 title "Alzheimer's disease, metal ions and metal homeostatic therapy" @default.
- W2025615265 cites W101981630 @default.
- W2025615265 cites W1517283793 @default.
- W2025615265 cites W1575039155 @default.
- W2025615265 cites W1602771322 @default.
- W2025615265 cites W1632936309 @default.
- W2025615265 cites W1661011319 @default.
- W2025615265 cites W1850016195 @default.
- W2025615265 cites W1876500712 @default.
- W2025615265 cites W1882847937 @default.
- W2025615265 cites W1963885312 @default.
- W2025615265 cites W1964624871 @default.
- W2025615265 cites W1966113666 @default.
- W2025615265 cites W1966618264 @default.
- W2025615265 cites W1967464880 @default.
- W2025615265 cites W1968675059 @default.
- W2025615265 cites W1970156306 @default.
- W2025615265 cites W1970159001 @default.
- W2025615265 cites W1971576287 @default.
- W2025615265 cites W1972543492 @default.
- W2025615265 cites W1976495019 @default.
- W2025615265 cites W1977277944 @default.
- W2025615265 cites W1981782871 @default.
- W2025615265 cites W1983761283 @default.
- W2025615265 cites W1984468350 @default.
- W2025615265 cites W1990112973 @default.
- W2025615265 cites W1997805873 @default.
- W2025615265 cites W2000706612 @default.
- W2025615265 cites W2002330213 @default.
- W2025615265 cites W2004546493 @default.
- W2025615265 cites W2005315872 @default.
- W2025615265 cites W2011574003 @default.
- W2025615265 cites W2011746987 @default.
- W2025615265 cites W2011810121 @default.
- W2025615265 cites W2014210332 @default.
- W2025615265 cites W2015747380 @default.
- W2025615265 cites W2017610860 @default.
- W2025615265 cites W2018014861 @default.
- W2025615265 cites W2018056213 @default.
- W2025615265 cites W2020497815 @default.
- W2025615265 cites W2021359823 @default.
- W2025615265 cites W2024084918 @default.
- W2025615265 cites W2025577312 @default.
- W2025615265 cites W2026536857 @default.
- W2025615265 cites W2029107363 @default.
- W2025615265 cites W2036670784 @default.
- W2025615265 cites W2036839645 @default.
- W2025615265 cites W2037387044 @default.
- W2025615265 cites W2038443140 @default.
- W2025615265 cites W2039264840 @default.
- W2025615265 cites W2039517040 @default.
- W2025615265 cites W2040336716 @default.
- W2025615265 cites W2042197652 @default.
- W2025615265 cites W2043228413 @default.
- W2025615265 cites W2046596211 @default.
- W2025615265 cites W2047735961 @default.
- W2025615265 cites W2048975745 @default.
- W2025615265 cites W2050529442 @default.
- W2025615265 cites W2051516838 @default.
- W2025615265 cites W2054072494 @default.
- W2025615265 cites W2055659156 @default.
- W2025615265 cites W2057726768 @default.
- W2025615265 cites W2058936552 @default.
- W2025615265 cites W2061821236 @default.
- W2025615265 cites W2062571325 @default.
- W2025615265 cites W2064962462 @default.
- W2025615265 cites W2066123662 @default.
- W2025615265 cites W2072415034 @default.
- W2025615265 cites W2075481535 @default.
- W2025615265 cites W2075725519 @default.
- W2025615265 cites W2075876062 @default.
- W2025615265 cites W2079887405 @default.
- W2025615265 cites W2080290961 @default.
- W2025615265 cites W2082469108 @default.
- W2025615265 cites W2083500052 @default.
- W2025615265 cites W2084174305 @default.
- W2025615265 cites W2084694548 @default.
- W2025615265 cites W2086142786 @default.
- W2025615265 cites W2087613580 @default.
- W2025615265 cites W2091384808 @default.
- W2025615265 cites W2091908180 @default.
- W2025615265 cites W2093477129 @default.
- W2025615265 cites W2096410114 @default.
- W2025615265 cites W2099018685 @default.
- W2025615265 cites W2099370040 @default.
- W2025615265 cites W2103440561 @default.
- W2025615265 cites W2105704879 @default.
- W2025615265 cites W2108471384 @default.
- W2025615265 cites W2110798854 @default.
- W2025615265 cites W2110888808 @default.