FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025621029> ?p ?o ?g. }

• W2025621029 endingPage "68" @default.
• W2025621029 startingPage "51" @default.
• W2025621029 abstract "Insertion of a short-sized epitope at four different sites of yeast-expressed hamster polyomavirus major capsid protein VP1 has been found to result in the formation of chimeric virus-like particles. Here, we demonstrate that the insertion of 45 or 120 amino acid–long segments from the N-terminus of Puumala hantavirus nucleocapsid protein into sites 1 (amino acids 80–89) and 4 (amino acids 288–295) of VP1 allowed the highly efficient formation of virus-like particles. In contrast, expression level and assembly capacity of fusions to sites 2 (amino acids 222–225) and 3 (amino acids 243–247) were drastically reduced. Immunization of BALB/c mice with chimeric virus-like particles induced a high-titered antibody response against the hantavirus nucleocapsid protein, even in the absence of any adjuvant. The strongest response was observed in mice immunized with virus-like particles harboring 120 amino acids of hantavirus nucleocapsid protein. According to the immunoglobulin subclass distribution of nucleocapsid protein-specific antibodies a mixed Th1/Th2 response was detected. The VP1 carrier itself also induced a mixed Th1/Th2 response, which was found to be reduced in mice immunized with virus-like particles harboring 120 amino acid–long inserts. In conclusion, hamster polyomavirus VP1 represents a promising carrier moiety for future vaccine development." @default.
• W2025621029 created "2016-06-24" @default.
• W2025621029 creator A5049618538 @default.
• W2025621029 creator A5051129046 @default.
• W2025621029 creator A5061691457 @default.
• W2025621029 creator A5069728174 @default.
• W2025621029 creator A5083753728 @default.
• W2025621029 creator A5086157441 @default.
• W2025621029 date "2004-03-01" @default.
• W2025621029 modified "2023-09-30" @default.
• W2025621029 title "Segments of Puumala Hantavirus Nucleocapsid Protein Inserted into Chimeric Polyomavirus-Derived Virus-Like Particles Induce a Strong Immune Response in Mice" @default.
• W2025621029 cites W1494330616 @default.
• W2025621029 cites W1518785179 @default.
• W2025621029 cites W1523991840 @default.
• W2025621029 cites W1853664782 @default.
• W2025621029 cites W1913502059 @default.
• W2025621029 cites W1928945856 @default.
• W2025621029 cites W1967780063 @default.
• W2025621029 cites W1972213702 @default.
• W2025621029 cites W1979001545 @default.
• W2025621029 cites W1979046045 @default.
• W2025621029 cites W1985649167 @default.
• W2025621029 cites W1987657010 @default.
• W2025621029 cites W1990439455 @default.
• W2025621029 cites W1990670165 @default.
• W2025621029 cites W1991656386 @default.
• W2025621029 cites W1994558598 @default.
• W2025621029 cites W2006664525 @default.
• W2025621029 cites W2019283575 @default.
• W2025621029 cites W2026446101 @default.
• W2025621029 cites W2027052868 @default.
• W2025621029 cites W2029464176 @default.
• W2025621029 cites W2030276103 @default.
• W2025621029 cites W2034067848 @default.
• W2025621029 cites W2040000590 @default.
• W2025621029 cites W2041219129 @default.
• W2025621029 cites W2045383465 @default.
• W2025621029 cites W2046679126 @default.
• W2025621029 cites W2048024207 @default.
• W2025621029 cites W2053449687 @default.
• W2025621029 cites W2069346403 @default.
• W2025621029 cites W2074832018 @default.
• W2025621029 cites W2086724856 @default.
• W2025621029 cites W2087579076 @default.
• W2025621029 cites W2091372450 @default.
• W2025621029 cites W2092815830 @default.
• W2025621029 cites W2097696280 @default.
• W2025621029 cites W2110893447 @default.
• W2025621029 cites W2113177912 @default.
• W2025621029 cites W2116063606 @default.
• W2025621029 cites W2128625665 @default.
• W2025621029 cites W2132868075 @default.
• W2025621029 cites W2140422292 @default.
• W2025621029 cites W2140613873 @default.
• W2025621029 cites W2146000257 @default.
• W2025621029 cites W2150142321 @default.
• W2025621029 cites W2158021888 @default.
• W2025621029 cites W2415465002 @default.
• W2025621029 cites W4231394943 @default.
• W2025621029 cites W63843901 @default.
• W2025621029 cites W72270811 @default.
• W2025621029 cites W87652383 @default.
• W2025621029 doi "https://doi.org/10.1089/088282404322875458" @default.
• W2025621029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15018662" @default.
• W2025621029 hasPublicationYear "2004" @default.
• W2025621029 type Work @default.
• W2025621029 sameAs 2025621029 @default.
• W2025621029 citedByCount "46" @default.
• W2025621029 countsByYear W20256210292012 @default.
• W2025621029 countsByYear W20256210292013 @default.
• W2025621029 countsByYear W20256210292014 @default.
• W2025621029 countsByYear W20256210292015 @default.
• W2025621029 countsByYear W20256210292016 @default.
• W2025621029 countsByYear W20256210292017 @default.
• W2025621029 countsByYear W20256210292018 @default.
• W2025621029 countsByYear W20256210292020 @default.
• W2025621029 countsByYear W20256210292021 @default.
• W2025621029 countsByYear W20256210292023 @default.
• W2025621029 crossrefType "journal-article" @default.
• W2025621029 hasAuthorship W2025621029A5049618538 @default.
• W2025621029 hasAuthorship W2025621029A5051129046 @default.
• W2025621029 hasAuthorship W2025621029A5061691457 @default.
• W2025621029 hasAuthorship W2025621029A5069728174 @default.
• W2025621029 hasAuthorship W2025621029A5083753728 @default.
• W2025621029 hasAuthorship W2025621029A5086157441 @default.
• W2025621029 hasConcept C153911025 @default.
• W2025621029 hasConcept C159047783 @default.
• W2025621029 hasConcept C159654299 @default.
• W2025621029 hasConcept C195616568 @default.
• W2025621029 hasConcept C202878990 @default.
• W2025621029 hasConcept C203014093 @default.
• W2025621029 hasConcept C2522874641 @default.
• W2025621029 hasConcept C2775992772 @default.
• W2025621029 hasConcept C2778801254 @default.
• W2025621029 hasConcept C2910208175 @default.
• W2025621029 hasConcept C515207424 @default.
• W2025621029 hasConcept C55493867 @default.
• W2025621029 hasConcept C86803240 @default.

• next