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- W2025621785 abstract "To the Editor: Though it was disappointing that the large randomized trial comparing two fractionation schemes in Group III rhabdomyosarcoma conducted by the Intergroup Rhabdomyosarcoma Group and reported in your journal by Donaldson et al. ( 1 Donaldson S.S. Meza J. Breneman J.C. et al. Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma—a report from the IRSG. Int J Radiat Oncol Biol Phys. 2001; 51: 718-728 Abstract Full Text Full Text PDF PubMed Scopus (169) Google Scholar ) did not show a local control or survival benefit, the authors did mention a number of important lessons learned. For example, slightly more acute toxicities were noted in the hyperfractionated radiotherapy (HFRT) arm as compared to the conventionally fractionated radiotherapy (CFRT) arm, because of the modest acceleration of the former. Although the topic was not discussed in the paper, this trial also serves as a fairly “pure” in vivo experiment to determine radiobiologic parameters of rhabdomyosarcoma. In particular, because the local control curves for the two arms were coincident with each other, the biologic equivalent dose (BED) should be identical for tumor control, allowing calculation of alpha over beta as demonstrated below. Regimen 1 (HFRT) total 59.4 Gy in n1 = 54 fractions of d1 = 1.1 Gy per fraction. Regimen 2 (CFRT) total 50.4 Gy in n2 = 28 fractions of d2 = 1.8 Gy per fraction. In response to Drs. Timmerman and MendoncaInternational Journal of Radiation Oncology, Biology, PhysicsVol. 54Issue 5Preview Full-Text PDF" @default.
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- W2025621785 date "2002-12-01" @default.
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- W2025621785 title "In regard to Donaldson et al: results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma—a report from the IRSG. IJROBP 2001;51:718–728" @default.
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- W2025621785 doi "https://doi.org/10.1016/s0360-3016(02)03015-8" @default.
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