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- W2025622078 abstract "The long-term effect of 6-HDA on operant behaviour is schedule-dependent; normal response patterns are maintained on FR and FI schedules, while an increase in responding gradually develops on a VI schedule. This effect appears to be related to altered function of central dopamine-containing neurons. 6-HDA-treated rats are more sensitive to AMT, suggesting that CA-containing neurons surviving 6-HDA treatment participate in maintaining the normal patterns of responding observed on the FR and FI schedules. Maintenance of normal function may also involve the development of central denervation supersensitivity which, as indicated by experiments with l-dopa, occurs soon after 6-HDA treatment. The rate-decreasing effect of d-amphetamine is unaltered in 6-HDA-treated rats while the rate-increasing effect is attenuated, consistent with proposals that the rate-increasing effect is mediated by release of catecholamines." @default.
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- W2025622078 date "1974-04-01" @default.
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- W2025622078 title "Behavioural pharmacology of 6-hydroxydopamine" @default.
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- W2025622078 doi "https://doi.org/10.1016/0006-2952(74)90085-9" @default.
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