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• W2025626677 abstract "We read the article by Kaasch et al. 1 Kaasch A.J. Rieg S. Hellmich M. Kern W.V. Seifert H. Differential time to positivity is not predictive for central line-related Staphylococcus aureus bloodstream infection in routine clinical care. J Infect. 2014; 68: 58-61 Abstract Full Text Full Text PDF PubMed Scopus (28) Google Scholar with great interest because the authors found a surprisingly low sensitivity (37%) and specifity (77%) of the routinely used differential time to positivity method (DTP) for detection of catheter-related bloodstream infection (CRBSI). This performance of DTP is markedly lower compared to previous data summarized in a recent review (sensitivity 89–90%, specificity 72–87%) 2 Raad I. Hanna H. Maki D. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis. 2007; 7: 645-657 Abstract Full Text Full Text PDF PubMed Scopus (384) Google Scholar and the original article published by Blot et al. (sensitivity 94%, specificity 91%; compared to quantitative catheter culture techniques). 3 Blot F. Nitenberg G. Chachaty E. Raynard B. Germann N. Antoun S. et al. Diagnosis of catheter-related bacteraemia: a prospective comparison of the time to positivity of hub-blood versus peripheral-blood cultures. Lancet. 1999; 354: 1071-1077 Abstract Full Text Full Text PDF PubMed Scopus (360) Google Scholar When interpreting the results of the study by Kaasch et al., three considerations should be taken into account. Differential time to positivity is not predictive for central line-related Staphylococcus aureus bloodstream infection in routine clinical careJournal of InfectionVol. 68Issue 1PreviewMany physicians rely on differential time to positivity (DTP) when diagnosing catheter-related bloodstream infection (CRBSI). We evaluated whether DTP from routine blood cultures can predict catheter-related Staphylococcus aureus bloodstream infection. Full-Text PDF Reply to Krause et al.Journal of InfectionVol. 69Issue 3PreviewWe thank Krause et al. for their valuable comment and want to take the opportunity to clarify some aspects. First, we wish to point out that this study was not designed to challenge the concept of differential time to positivity (DTP) in its power to predict CRBSI per se. In contrary, the study was designed to examine the utility of DTP in terms of positive and negative predictive values measured under ‘real-life’ conditions. In this study, ‘real life’ means that a 24/7 microbiology service was not available and blood cultures were drawn within the clinical routine and not specifically ordered for the study. Full-Text PDF" @default.
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• W2025626677 title "Differential time to positivity is not predictive for central line-related Staphylococcus aureus bloodstream infection in routine clinical care" @default.
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• W2025626677 doi "https://doi.org/10.1016/j.jinf.2014.05.009" @default.
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