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- W2025643407 abstract "Polyethylene terephthalate in textile form (Dacron®) has been used extensively as a surgical implant material for applications such as vascular grafts and percutaneous access devices. It is moderately histocompatible eliciting a chronic inflammatory reaction predominnately in tissue which has grown into the pores of the fabric. Titanium implants on the other hand, induce only the slightest inflammatory response and connective tissue adhesion to the titanium oxide surface is excellent. It was, therefore, hypothesized that a titanium coating on Dacron® fabric might improve its histocompatibility while leaving its desirable mechanical properties unaffected. To test this idea, Dacron® velour specimens were coated with titanium by vacuum deposition and were implanted together with uncoated controls in rabbits subcutis. After various implantation times, the specimens were recovered and the associated tissue was examined histologically. Qualitative and semiquantitative analysis revealed that tissue ingrowth quantity and quality was highly variable, not only between test and control specimens, but also between animals and even between specimens within the same animal. This indicated that there may be a number of factors influencing tissue ingrowth that were not adequately controlled in this study. The titanium coating which was undoubtedly highly oxidized had a profound qualitative and quantitative effect on fibroblast activity (ground substance formation) and fibroblast adhesion to the Dacron® fibers. The results obtained after these short-term implantation periods indicate that titanium coating affects the quality of the interfacing tissue and may actually improve long-term histocompatibility. Long-term studies will have to confirm these preliminary data." @default.
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- W2025643407 title "Titanium-coated dacron® velour: A study of interfacial connective tissue formation" @default.
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- W2025643407 doi "https://doi.org/10.1002/jbm.820230204" @default.
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