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• W2025643708 abstract "<h2>Abstract</h2><h3>Objective</h3> To compare the effects of four different regimens including oral and transdermal formulations with or without progestins on the hemostatic system in a prospective randomized fashion. <h3>Methods</h3> Eighty-eight women were randomized to four groups receiving continuous transdermal estradiol 50μg/day (tE₂), oral conjugated equine estrogen 0.625mg/day (CEE 0.625mg), oral conjugated equine estrogen 0.625mg/day plus medroxyprogesterone acetate 2.5mg/day (CEE 0.625mg/MPA 2.5mg), or oral 2mg 17-β estradiol combined with 1mg norethistrone acetate (E₂/norethistrone). The hysterectomized patients received only estrogen, and the remaining women received the estrogen plus progesterone combination regimens. As a marker of hemostatic system fibrinogen, tissue plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) levels were measured initially, and after 1 and 6 months of therapy. <h3>Results</h3> The treatment groups were well matched for baseline characteristics including age, height, weight, body mass index, and systolic and diastolic blood pressures. During the study period fibrinogen levels were below the baseline values in all groups. However, the decrease was only statistically significant in patients treated with oral 0.625mg/day CEE. tPA levels were decreased significantly by tE₂, CEE 0.625mg, and CEE 0.625mg/MPA 2.5mg. PAI-1 levels were decreased significantly by CEE 0.625mg, and CEE 0.625mg/MPA 2.5mg. When the effects of the four different regimens were compared using percentage changes from the baseline, no significant difference was found among the treatment groups. <h3>Conclusion</h3> one of the treatment regimens resulted in a more coagulable state. Oral therapy with CEE decreased the levels of all parameters, and MPA did not impair this beneficial effect, except for in fibrinogen. Transdermal therapy had a minimal effect. No significant difference was noted among the four regimens." @default.
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• W2025643708 date "2006-02-01" @default.
• W2025643708 modified "2023-10-07" @default.
• W2025643708 title "Effects of four different regimens of hormone replacement therapy on hemostatic parameters: A prospective randomized study" @default.
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• W2025643708 doi "https://doi.org/10.1016/j.maturitas.2005.05.010" @default.
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