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- W2025644439 abstract "新規システイン誘導体であるフドステイン [(-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid] の気道分泌に対する作用をウサギおよびラットを用いて検討した.ウサギにおける気道内色素排泄量を気道分泌の間接的な指標にしたところ,フドステイン500mg/kgの経ロ投与は,気道内色素量を有意に増加させた.一方, Perry and Boyd の変法を用いて,ウサギの気道液を直接的に採取したところ,フドステイン500mg/kgの経ロ投与は,投与3時間後までの気道液量を有意に増加させた.なお,この時の気道液中に含有されるタンパク質およびホスファチジルコリン含量は,有意な変化を認めなかった.次に,気道の漿液性分泌に対するフドステインの作用を検討した.フドステイン500mg/kgの経ロ投与は,ラット気管支肺胞洗浄液中において漿液性分泌の指標であるクロライドイオン濃度を有意に増加させた.一方,カルボシステイン500mg/kgの経ロ投与は,気道分泌に対して影響しなかった.次に, in vitro における検討を行ったところ,フドステイン(10-2M)は粘液溶解作用を示さず,肺胞II型上皮細胞からのホスファチジルコリン分泌に対しても影響を認めなかった.以上,高用量のフドステインは漿液性分泌を伴う気道分泌促進作用を認め,従来のシステイン系去痰薬では認められない作用を有していると考えられる." @default.
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- W2025644439 title "Effects of fudosteine, a new cysteine derivative, on airway secretion in rabbits and rats." @default.
- W2025644439 doi "https://doi.org/10.1254/fpj.116.371" @default.
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