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• W2025647550 abstract "In a λimm434 lysogen, two proteins are expressed from the integrated prophage. Both are encoded by the same mRNA whose transcription initiates at the PRM promoter. One protein is the 434 repressor, needed for the establishment and maintenance of lysogeny. The other is Hex which is translated from an open reading frame that apparently partially overlaps the 434 repressor coding region. In the wild type host, disruption of the gene encoding Hex destabilizes λimm434 lysogens. However, the hex mutation has no effect on lysogen stability in a recA− host. These observations suggest that Hex functions by modulating the ability of RecA to stimulate 434 repressor autocleavage. We tested this hypothesis by identifying and purifying Hex to determine if this protein inhibited RecA‑stimulated autocleavage of 434 repressor in vitro. Our results show that in vitro a fragment of Hex prevents RecA-stimulated autocleavage of 434 repressor, as well as the repressors of the closely related phage P22. Surprisingly, Hex does not prevent RecA‑stimulated autocleavage of phage lambda repressor, nor the E. coli LexA repressor." @default.
• W2025647550 created "2016-06-24" @default.
• W2025647550 creator A5004152308 @default.
• W2025647550 creator A5047846728 @default.
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• W2025647550 date "2013-01-09" @default.
• W2025647550 modified "2023-09-26" @default.
• W2025647550 title "Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage" @default.
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• W2025647550 doi "https://doi.org/10.3390/v5010111" @default.
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