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- W2025649211 abstract "The effect on the fibrinolysic factors was investigated in a cross-over study in young healthy volunteers receiving 2500, 5000, or 10000 XaI units of low molecular weight heparin sc, 5000 XaI units of conventional heparin sc, and compared with a control group. A variation of tPA inhibitor activity was seen with a significant decrease (p<0.001) at 11.15 a.m., 4 h after the heparin injection, and the tPA inhibitor remained decreased at 6 and 8h. Also the tPA:Ag decreased but a significant decrease was not seen until at 1.15 p.m. The same decrease in tPA inhibitor activity and tPA:Ag was seen in the control group, which did not receive any heparin. Thus the decrease of tPA inhibitor as well as the shortened euglobulin clot lysis time found could not be attributed to heparin. No influence was seen on plasminogen or α2-antiplasmin. It seems that increased fibrinolysis during the day may result from the variation of tPA inhibitor during the day. Therefore, when an increased fibrinolysis is seen, it is necessary to take the time of the blood sampling into account." @default.
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- W2025649211 date "1987-01-01" @default.
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- W2025649211 title "tPA inhibitor, tPA:Ag, plasminogen, and α2-antiplasmin after low molecular weight heparin or standard heparin" @default.
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- W2025649211 doi "https://doi.org/10.1016/0268-9499(87)90031-2" @default.
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