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- W2025651648 abstract "T cell subsets that produce minor lymphocyte stimulatory (Mls) antigens were analyzed using mixed lymphocyte reaction (MLR) in vitro or clonal elimination assay in vivo. When lymph node T cells from B1O.BR (Mls-1b) mice were stimulated with various T cell subsets from AKR (Mls-1a) mice in the presence of B10.BR antigen presenting cells (APC), proportions of Mls-1a reactive T cell blasts (Vβ6+, Vβ8.1+) increased. The stimulatory potency of CD8+ T cells was higher than that of CD4+ T cells. Furthermore, among either CD8+ or CD4+ T cell subset, CD44+ T cells appeared to produce larger amounts of Mls-1a antigens than CD44- T cells. More marked difference was demonstrated, when stimulator AKR T cells were being activated by immobilized anti-T cell antigen receptor (TCR) antibody during MLR. Thus, AKR T cells appeared to produce large amounts of Mls-1a antigens on appropriate stimulations. These findings were confirmed bv the semiquantitative analysis of mRNA levels of MTV -7 in the AKR T cell subsets. When CD8+CD44+ T cells from (AKR x B 10.BR)F1 mice were injected intravenously into [B10.BR → B 10.BR] syngeneic bone marrow (BM) chimeras 1 week after BM reconstitution and proportions of Vβ6+ T cells were quantitated 7 weeks later, significant clonal elimination of Vβ6+ T cells was induced among both thymocyte population and lymph node T cell population in a dose-dependent manner of the inoculated F1 T cells. Inoculation of CD8+CD44- F1 T cells eliminated Vβ6+ T cells less efficiently from lymph node T cells and inoculation of CD4+ F1 T cells induced no significant clonal elimination of the Vβ6+ T cells. The present findings demonstrate clearly that CD8+CD44+ T cells" @default.
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- W2025651648 date "1995-08-01" @default.
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- W2025651648 title "Production of Minor Lymphocyte Stimulatory-1a Antigens from T Cell Subsets" @default.
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- W2025651648 doi "https://doi.org/10.1016/s0171-2985(11)80425-0" @default.
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