Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025654004> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2025654004 endingPage "214" @default.
- W2025654004 startingPage "214" @default.
- W2025654004 abstract "The challenge of accurately predicting human clinical outcome based on preclinical data has led to a high failure rate of compounds in human clinical trials. A series of methods are described by which biosimulation can address these challenges and guide the design and evaluation of experimental and clinical protocols. Early compound development often proceeds on the basis of preclinical data from animal models. The systematic evaluation possible in a simulation can assist in the critical step of translating the preclinical outcomes to human physiology. Later in the process, clinical trials definitively establish a therapy's beneficial effects, as well as any adverse side effects. Biosimulation allows for the optimal design of clinical trials to ensure that key issues are addressed effectively and efficiently, and in doing so, improves the success rate of the trials." @default.
- W2025654004 created "2016-06-24" @default.
- W2025654004 creator A5001500144 @default.
- W2025654004 creator A5040766516 @default.
- W2025654004 date "2005-01-01" @default.
- W2025654004 modified "2023-10-10" @default.
- W2025654004 title "Application of predictive biosimulation within pharmaceutical clinical development: examples of significance for translational medicine and clinical trial design" @default.
- W2025654004 cites W1606168019 @default.
- W2025654004 cites W1982371325 @default.
- W2025654004 cites W2102695671 @default.
- W2025654004 cites W2121175754 @default.
- W2025654004 doi "https://doi.org/10.1049/ip-syb:20050043" @default.
- W2025654004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16986263" @default.
- W2025654004 hasPublicationYear "2005" @default.
- W2025654004 type Work @default.
- W2025654004 sameAs 2025654004 @default.
- W2025654004 citedByCount "31" @default.
- W2025654004 countsByYear W20256540042012 @default.
- W2025654004 countsByYear W20256540042013 @default.
- W2025654004 countsByYear W20256540042016 @default.
- W2025654004 countsByYear W20256540042017 @default.
- W2025654004 countsByYear W20256540042018 @default.
- W2025654004 countsByYear W20256540042019 @default.
- W2025654004 countsByYear W20256540042020 @default.
- W2025654004 countsByYear W20256540042022 @default.
- W2025654004 countsByYear W20256540042023 @default.
- W2025654004 crossrefType "journal-article" @default.
- W2025654004 hasAuthorship W2025654004A5001500144 @default.
- W2025654004 hasAuthorship W2025654004A5040766516 @default.
- W2025654004 hasConcept C112930515 @default.
- W2025654004 hasConcept C142724271 @default.
- W2025654004 hasConcept C148482608 @default.
- W2025654004 hasConcept C177713679 @default.
- W2025654004 hasConcept C19527891 @default.
- W2025654004 hasConcept C2780035454 @default.
- W2025654004 hasConcept C41008148 @default.
- W2025654004 hasConcept C535046627 @default.
- W2025654004 hasConcept C64903051 @default.
- W2025654004 hasConcept C71924100 @default.
- W2025654004 hasConcept C98274493 @default.
- W2025654004 hasConceptScore W2025654004C112930515 @default.
- W2025654004 hasConceptScore W2025654004C142724271 @default.
- W2025654004 hasConceptScore W2025654004C148482608 @default.
- W2025654004 hasConceptScore W2025654004C177713679 @default.
- W2025654004 hasConceptScore W2025654004C19527891 @default.
- W2025654004 hasConceptScore W2025654004C2780035454 @default.
- W2025654004 hasConceptScore W2025654004C41008148 @default.
- W2025654004 hasConceptScore W2025654004C535046627 @default.
- W2025654004 hasConceptScore W2025654004C64903051 @default.
- W2025654004 hasConceptScore W2025654004C71924100 @default.
- W2025654004 hasConceptScore W2025654004C98274493 @default.
- W2025654004 hasIssue "4" @default.
- W2025654004 hasLocation W20256540041 @default.
- W2025654004 hasLocation W20256540042 @default.
- W2025654004 hasOpenAccess W2025654004 @default.
- W2025654004 hasPrimaryLocation W20256540041 @default.
- W2025654004 hasRelatedWork W1576735944 @default.
- W2025654004 hasRelatedWork W2067584555 @default.
- W2025654004 hasRelatedWork W2126486918 @default.
- W2025654004 hasRelatedWork W2128497441 @default.
- W2025654004 hasRelatedWork W2409877361 @default.
- W2025654004 hasRelatedWork W2470067656 @default.
- W2025654004 hasRelatedWork W2609919755 @default.
- W2025654004 hasRelatedWork W2799753303 @default.
- W2025654004 hasRelatedWork W585940761 @default.
- W2025654004 hasRelatedWork W2188607138 @default.
- W2025654004 hasVolume "152" @default.
- W2025654004 isParatext "false" @default.
- W2025654004 isRetracted "false" @default.
- W2025654004 magId "2025654004" @default.
- W2025654004 workType "article" @default.