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- W2025657639 abstract "As an animal model of severe acute pancreatitis (SAP), rat bile salt-induced pancreatitis is frequently employed. However, in vivo models have limitations concerning the analysis of the molecular mechanism. We have already disclosed that apoptosis is involved in the mechanism of organ dysfunction during SAP, and that PAAF (pancreatitis-associated ascitic fluid) has the ability to induce apoptosis. Recently, we showed that the breakdown of the intestinal mucosa via accelerated apoptosis increased the intestinal permeability in rat SAP. To investigate the mechanism of increased permeability, we established an in vitro model. T84 cells were grown on Transwell, and PAAF was added to the basolateral side of the well. TEER (transepithelial electrical resistance) was measured for the assessment of cellular permeability. This model well reproduced the in vivo phenomenon, meaning that PAAF decreased TEER without affecting the tight junction and induced apoptosis in T84 cells. We think that this model will be useful for investigating the molecular mechanism of organ dysfunction and bacterial translocation during SAP." @default.
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- W2025657639 date "2009-07-01" @default.
- W2025657639 modified "2023-10-14" @default.
- W2025657639 title "In Vitro Pancreatitis Model Using Pancreatitis-Associated Ascitic Fluid" @default.
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- W2025657639 doi "https://doi.org/10.1097/01.mpa.0000357023.77297.30" @default.
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