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- W2025660893 endingPage "9312" @default.
- W2025660893 startingPage "9312" @default.
- W2025660893 abstract "The single crystal X-ray structure of the newly synthesized ruthenium (II)-polypyridyl complex, [(bpy)2Ru(L)](PF6)2 (1) (bpy is 2,2′-bipyridyl and L is 2-methyl-2H-1,3,7,8-tetraaza-cyclopenta[l]phenanthren-2-ol revealed a near planar conformation for the fused imidazole moiety, suggesting the complex may be capable of binding to duplex DNA. Binding-induced changes in spectral properties, along with thermal denaturation and viscosity measurement studies confirmed that the complex binds to CT-DNA with a moderately high binding constant value (4.1 × 105 M−1) through intercalation. Photocleavage studies with the pBR322 plasmid DNA were performed following excitation of this complex into the Ru(dπ) → bpy/L(π*)-based MLCT band and have shown that this complex cleaves the circular pBR322 DNA into linear DNA. Inhibitor studies revealed that the hydroxyl radicals were mainly responsible for the DNA photocleavage reaction. Preliminary studies indicate that the –OH functionality in 1 was also found to hydrolyse the phosphodiester linkage of pBR322 in the dark." @default.
- W2025660893 created "2016-06-24" @default.
- W2025660893 creator A5017391319 @default.
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- W2025660893 date "2009-01-01" @default.
- W2025660893 modified "2023-10-18" @default.
- W2025660893 title "DNA binding and cleavage properties of a newly synthesised Ru(II)-polypyridyl complex" @default.
- W2025660893 cites W1638094223 @default.
- W2025660893 cites W1964305006 @default.
- W2025660893 cites W1970393749 @default.
- W2025660893 cites W1970455635 @default.
- W2025660893 cites W1970982697 @default.
- W2025660893 cites W1971920947 @default.
- W2025660893 cites W1972043451 @default.
- W2025660893 cites W1972348142 @default.
- W2025660893 cites W1974234898 @default.
- W2025660893 cites W1975402304 @default.
- W2025660893 cites W1976952192 @default.
- W2025660893 cites W1978606639 @default.
- W2025660893 cites W1980215836 @default.
- W2025660893 cites W1986956695 @default.
- W2025660893 cites W1987068145 @default.
- W2025660893 cites W1987586745 @default.
- W2025660893 cites W1987679692 @default.
- W2025660893 cites W1987854733 @default.
- W2025660893 cites W1988753748 @default.
- W2025660893 cites W1991471453 @default.
- W2025660893 cites W1993631374 @default.
- W2025660893 cites W1995810957 @default.
- W2025660893 cites W2003465708 @default.
- W2025660893 cites W2006524033 @default.
- W2025660893 cites W2009046603 @default.
- W2025660893 cites W2011067230 @default.
- W2025660893 cites W2012996727 @default.
- W2025660893 cites W2013914883 @default.
- W2025660893 cites W2014588550 @default.
- W2025660893 cites W2018837467 @default.
- W2025660893 cites W2023465630 @default.
- W2025660893 cites W2026725853 @default.
- W2025660893 cites W2027930950 @default.
- W2025660893 cites W2030133358 @default.
- W2025660893 cites W2032167634 @default.
- W2025660893 cites W2036213136 @default.
- W2025660893 cites W2037629823 @default.
- W2025660893 cites W2038601931 @default.
- W2025660893 cites W2038822441 @default.
- W2025660893 cites W2039318684 @default.
- W2025660893 cites W2041098061 @default.
- W2025660893 cites W2042062103 @default.
- W2025660893 cites W2042308077 @default.
- W2025660893 cites W2042521338 @default.
- W2025660893 cites W2042931635 @default.
- W2025660893 cites W2044851985 @default.
- W2025660893 cites W2049191611 @default.
- W2025660893 cites W2052752040 @default.
- W2025660893 cites W2054835125 @default.
- W2025660893 cites W2055263756 @default.
- W2025660893 cites W2059100663 @default.
- W2025660893 cites W2062328767 @default.
- W2025660893 cites W2064952427 @default.
- W2025660893 cites W2069067022 @default.
- W2025660893 cites W2077269625 @default.
- W2025660893 cites W2083318148 @default.
- W2025660893 cites W2083355060 @default.
- W2025660893 cites W2084430744 @default.
- W2025660893 cites W2088167348 @default.
- W2025660893 cites W2088607843 @default.
- W2025660893 cites W2091165867 @default.
- W2025660893 cites W2093008118 @default.
- W2025660893 cites W2093282189 @default.
- W2025660893 cites W2093780700 @default.
- W2025660893 cites W2094012917 @default.
- W2025660893 cites W2094171960 @default.
- W2025660893 cites W2098147700 @default.
- W2025660893 cites W2105302993 @default.
- W2025660893 cites W2116177049 @default.
- W2025660893 cites W2117476471 @default.
- W2025660893 cites W2118345116 @default.
- W2025660893 cites W2120939781 @default.
- W2025660893 cites W2129239955 @default.
- W2025660893 cites W2258820226 @default.
- W2025660893 cites W2324613566 @default.
- W2025660893 cites W2949467840 @default.
- W2025660893 cites W2950547848 @default.
- W2025660893 cites W2952314914 @default.
- W2025660893 cites W4211015427 @default.
- W2025660893 cites W4251268600 @default.
- W2025660893 cites W4251754471 @default.
- W2025660893 cites W74691089 @default.
- W2025660893 doi "https://doi.org/10.1039/b906756f" @default.
- W2025660893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20449211" @default.
- W2025660893 hasPublicationYear "2009" @default.