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- W2025683994 abstract "In this study we investigated the hypothesis that the decrease in pulmonary vascular pressures observed after administration of nitroglycerin is in part due to a shift in the pulmonary vascular pressure-volume relationship. The experiments were done in six closed-chest dogs anesthetized with pentobarbital, in which pulmonary, cardiac, and intestinal relative blood volumes were determined by equilibrium blood pool scintigraphy. Nitroglycerin (30 μg/kg/min) caused 7% (p < 0.02) and 12% (p < 0.02) reductions in pulmonary and total cardiac blood volume, respectively, and a 7% (p < 0.01) increase in intestinal blood volume. This shift of blood from the heart and the pulmonary circulation to the systemic (intestinal) circulation was accompanied by reductions in mean pulmonary artery pressure from 16 ± 2 mm Hg to 12 ± 1 mm Hg (p < 0.01), in mean pulmonary capillary wedge pressure from 11 ± 2 mm Hg to 6 ± 1 mm Hg (p < 0.01), and in mean portal pressure from 9 ± 1 mm Hg to 8 ± 1 mm Hg (p < 0.01). The position of the pulmonary vascular pressure-blood volume relationship was unaffected by nitroglycerin, whereas the portal pressure-intestinal blood volume relationship was shifted to the left and upward. These changes suggest that pulmonary vascular tone remained unchanged, whereas intestinal vascular tone decreased during administration of nitroglycerin. In conclusion, nitroglycerin decreased pulmonary vascular pressures through a passive emptying of the pulmonary circulation as a result of increased systemic (intestinal) vascular capacitance." @default.
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- W2025683994 date "1991-05-01" @default.
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- W2025683994 title "The effect of nitroglycerin on pulmonary vascular capacitance in dogs" @default.
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- W2025683994 doi "https://doi.org/10.1016/0002-8703(91)90152-8" @default.
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