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• W2025687548 endingPage "e89123" @default.
• W2025687548 startingPage "e89123" @default.
• W2025687548 abstract "Traditional Chinese medicine (TCM) has unique therapeutic effects for complex chronic diseases. However, for the lack of an effective systematic approach, the research progress on the effective substances and pharmacological mechanism of action has been very slow. In this paper, by incorporating network biology, bioinformatics and chemoinformatics methods, an integrated approach was proposed to systematically investigate and explain the pharmacological mechanism of action and effective substances of TCM. This approach includes the following main steps: First, based on the known drug targets, network biology was used to screen out putative drug targets; Second, the molecular docking method was used to calculate whether the molecules from TCM and drug targets related to chronic kidney diseases (CKD) interact or not; Third, according to the result of molecular docking, natural product-target network, main component-target network and compound-target network were constructed; Finally, through analysis of network characteristics and literature mining, potential effective multi-components and their synergistic mechanism were putatively identified and uncovered. Bu-shen-Huo-xue formula (BSHX) which was frequently used for treating CKD, was used as the case to demonstrate reliability of our proposed approach. The results show that BSHX has the therapeutic effect by using multi-channel network regulation, such as regulating the coagulation and fibrinolytic balance, and the expression of inflammatory factors, inhibiting abnormal ECM accumulation. Tanshinone IIA, rhein, curcumin, calycosin and quercetin may be potential effective ingredients of BSHX. This research shows that the integration approach can be an effective means for discovering active substances and revealing their pharmacological mechanisms of TCM." @default.
• W2025687548 created "2016-06-24" @default.
• W2025687548 creator A5013747303 @default.
• W2025687548 creator A5028889141 @default.
• W2025687548 creator A5040006210 @default.
• W2025687548 creator A5049211356 @default.
• W2025687548 creator A5067748814 @default.
• W2025687548 creator A5073388714 @default.
• W2025687548 creator A5083809384 @default.
• W2025687548 date "2014-03-05" @default.
• W2025687548 modified "2023-10-10" @default.
• W2025687548 title "A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease" @default.
• W2025687548 cites W1490626457 @default.
• W2025687548 cites W1500505519 @default.
• W2025687548 cites W1522650590 @default.
• W2025687548 cites W1541803468 @default.
• W2025687548 cites W1549626617 @default.
• W2025687548 cites W1597114022 @default.
• W2025687548 cites W1680799241 @default.
• W2025687548 cites W1759780789 @default.
• W2025687548 cites W1870797623 @default.
• W2025687548 cites W1967041070 @default.
• W2025687548 cites W1969209081 @default.
• W2025687548 cites W1970338380 @default.
• W2025687548 cites W1971116512 @default.
• W2025687548 cites W1972713500 @default.
• W2025687548 cites W1974944535 @default.
• W2025687548 cites W1975651332 @default.
• W2025687548 cites W1977036923 @default.
• W2025687548 cites W1980441695 @default.
• W2025687548 cites W1981465339 @default.
• W2025687548 cites W1982147832 @default.
• W2025687548 cites W1983105444 @default.
• W2025687548 cites W1983400860 @default.
• W2025687548 cites W1983595568 @default.
• W2025687548 cites W1984035909 @default.
• W2025687548 cites W1984602225 @default.
• W2025687548 cites W1986562384 @default.
• W2025687548 cites W1988098595 @default.
• W2025687548 cites W1989511471 @default.
• W2025687548 cites W1992455089 @default.
• W2025687548 cites W1996390519 @default.
• W2025687548 cites W1997665934 @default.
• W2025687548 cites W1998166046 @default.
• W2025687548 cites W1998988595 @default.
• W2025687548 cites W1999084074 @default.
• W2025687548 cites W1999103998 @default.
• W2025687548 cites W1999374542 @default.
• W2025687548 cites W2000158535 @default.
• W2025687548 cites W2001552323 @default.
• W2025687548 cites W2003344667 @default.
• W2025687548 cites W2003765901 @default.
• W2025687548 cites W2004638606 @default.
• W2025687548 cites W2005795522 @default.
• W2025687548 cites W2007245700 @default.
• W2025687548 cites W2008255547 @default.
• W2025687548 cites W2008962951 @default.
• W2025687548 cites W2009313526 @default.
• W2025687548 cites W2011550183 @default.
• W2025687548 cites W2017112960 @default.
• W2025687548 cites W2018243063 @default.
• W2025687548 cites W2020541351 @default.
• W2025687548 cites W2021232559 @default.
• W2025687548 cites W2021928474 @default.
• W2025687548 cites W2022888921 @default.
• W2025687548 cites W2023521391 @default.
• W2025687548 cites W2023997709 @default.
• W2025687548 cites W2024802302 @default.
• W2025687548 cites W2024929099 @default.
• W2025687548 cites W2025311046 @default.
• W2025687548 cites W2025508421 @default.
• W2025687548 cites W2026152558 @default.
• W2025687548 cites W2027422401 @default.
• W2025687548 cites W2028225313 @default.
• W2025687548 cites W2032046156 @default.
• W2025687548 cites W2032672604 @default.
• W2025687548 cites W2035488076 @default.
• W2025687548 cites W2035713373 @default.
• W2025687548 cites W2035869224 @default.
• W2025687548 cites W2038107906 @default.
• W2025687548 cites W2038558596 @default.
• W2025687548 cites W2038796248 @default.
• W2025687548 cites W2039224269 @default.
• W2025687548 cites W2040272329 @default.
• W2025687548 cites W2042641422 @default.
• W2025687548 cites W2042842612 @default.
• W2025687548 cites W2044776012 @default.
• W2025687548 cites W2045516356 @default.
• W2025687548 cites W2046535832 @default.
• W2025687548 cites W2046748182 @default.
• W2025687548 cites W2048296798 @default.
• W2025687548 cites W2057389254 @default.
• W2025687548 cites W2059471041 @default.
• W2025687548 cites W2060039822 @default.
• W2025687548 cites W2061136308 @default.
• W2025687548 cites W2064067552 @default.
• W2025687548 cites W2066028265 @default.
• W2025687548 cites W2067924741 @default.

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