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• W2025687626 abstract "Here we investigated the anti-inflammatory properties of Ocotea quixos essential oil and of its main components, trans-cinnamaldehyde and methyl cinnamate, in in vitro and in vivo models. Ocotea essential oil and trans-cinnamaldehyde but not methyl cinnamate significantly reduced LPS-induced NO release from J774 macrophages at non-toxic concentrations, inhibited LPS-induced COX-2 expression and increased forskolin-induced cAMP production. The essential oil (30–100 mg/kg os) and trans-cinnamaldehyde (10 mg/kg os) in carrageenan-induced rat paw edema showed anti-inflammatory effect without damaging gastric mucosa. In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of O. quixos essential oil." @default.
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• W2025687626 date "2010-06-01" @default.
• W2025687626 modified "2023-10-18" @default.
• W2025687626 title "Ocotea quixos Lam. essential oil: In vitro and in vivo investigation on its anti-inflammatory properties" @default.
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• W2025687626 doi "https://doi.org/10.1016/j.fitote.2009.10.002" @default.
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