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- W2025689519 abstract "A convenient preparation of high-purity 1-chloro-2,6-difluorobenzene has been developed. The key to the isolation of the desired isomer, without contamination of the difficult-to-separate isomer 1-chloro-2,3-difluorobenzene, is the use of sulfonyl chloride to direct fluorine substitution to the ortho and para positions of the aryl ring. Although activation with sulfonyl chloride requires additional reaction steps, the process results in good overall yield and requires only low-cost commodity chemicals. The high-purity 1-chloro-2,6-difluorobenzene is useful as an intermediate for active ingredients in agricultural and pharmaceutical applications." @default.
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- W2025689519 date "2003-09-06" @default.
- W2025689519 modified "2023-09-24" @default.
- W2025689519 title "A Convenient Synthesis of High-Purity 1-Chloro-2,6-difluorobenzene" @default.
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- W2025689519 doi "https://doi.org/10.1021/op0340816" @default.
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