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- W2025702488 abstract "We have previously shown that local infection of tobacco plants with tobacco mosaic virus (TMV) or oilseed rape mosaic virus (ORMV) results in a systemic increase in the homologous recombination frequency (HRF). Here, we analyzed what other changes in the genome are triggered by pathogen infection. For the analysis of HRF, mutation frequency (MF) and microsatellite instability (MI), we used three different transgenic Arabidopsis lines carrying β-glucuronidase (GUS)-based substrates in their genome. We found that local infection of Arabidopsis with ORMV resulted in an increase of all three frequencies, albeit to differing degrees. The most prominent increase was observed in microsatellite instability. The increase in HRF was the lowest, although still statistically significant. The analysis of methylation of the 35S promoter and transgene expression showed that the greater instability of the transgene was not attributed to these changes. Strand breaks brought about a significant increase in non-treated tissues of infected plants. The expression of genes associated with various repair processes, such as KU70, RAD51, MSH2, DNA POL α and DNA POL δ, was also increased. To summarize, our data demonstrate that local ORMV infection destabilizes the genome in systemic tissues of Arabidopsis plants in various ways resulting in large rearrangements, point mutations and microsatellite instability." @default.
- W2025702488 created "2016-06-24" @default.
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- W2025702488 date "2011-05-01" @default.
- W2025702488 modified "2023-10-16" @default.
- W2025702488 title "Local infection with oilseed rape mosaic virus promotes genetic rearrangements in systemic Arabidopsis tissue" @default.
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- W2025702488 cites W1977897196 @default.
- W2025702488 cites W1978734059 @default.
- W2025702488 cites W1982778124 @default.
- W2025702488 cites W1987637262 @default.
- W2025702488 cites W1993983442 @default.
- W2025702488 cites W1994545768 @default.
- W2025702488 cites W199496729 @default.
- W2025702488 cites W1995654069 @default.
- W2025702488 cites W1998180584 @default.
- W2025702488 cites W2004164808 @default.
- W2025702488 cites W2008485368 @default.
- W2025702488 cites W2029937437 @default.
- W2025702488 cites W2030819518 @default.
- W2025702488 cites W2032302067 @default.
- W2025702488 cites W2034121965 @default.
- W2025702488 cites W2036693641 @default.
- W2025702488 cites W2037797217 @default.
- W2025702488 cites W2039862710 @default.
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- W2025702488 cites W2067971481 @default.
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- W2025702488 doi "https://doi.org/10.1016/j.mrfmmm.2011.02.014" @default.
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