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• W2025706053 abstract "A novel series of TNF-α convertase (TACE) inhibitors which are non-hydroxamate have been discovered. These compounds are bis-amides of l-tartaric acid (tartrate) and coordinate to the active site zinc in a tridentate manner. They are selective for TACE over other MMP’s. We report the first X-ray crystal structure for a tartrate-based TACE inhibitor." @default.
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• W2025706053 date "2010-02-01" @default.
• W2025706053 modified "2023-10-18" @default.
• W2025706053 title "The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors" @default.
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• W2025706053 doi "https://doi.org/10.1016/j.bmcl.2009.12.004" @default.
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