Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025707029> ?p ?o ?g. }
- W2025707029 endingPage "148" @default.
- W2025707029 startingPage "132" @default.
- W2025707029 abstract "We have identified two Xenopus mRNAs that encode proteins homologous to a component of the Wnt/beta-catenin transcriptional machinery known as Pygopus. The predicted proteins encoded by both mRNAs share the same structural properties with human Pygo-2, but with Xpygo-2alpha having an additional 21 N-terminal residues. Xpygo-2alpha messages accumulate in the prospective anterior neural plate after gastrulation and then are localized to the nervous system, rostral to and including the hindbrain. Xpygo-2beta mRNA is expressed in oocytes and early embryos but declines in level before and during gastrulation. In late neurula, Xpygo-2beta mRNA is restricted to the retinal field, including eye primordia and prospective forebrain. A C-terminal truncated mutant of Xpygo-2 containing the N-terminal Homology Domain (NHD) caused both axis duplication when injected at the 2-cell stage and inhibition of anterior neural development when injected in the prospective head, mimicking the previously described effects of Wnt-signaling activators. Inhibition of Xpygo-2alpha and Xpygo-2beta by injection of gene-specific antisense morpholino oligonucleotides into prospective anterior neurectoderm caused brain defects that were prevented by coinjection of Xpygo-2 mRNA. Both Xpygo-2alpha and Xpygo-2beta morpholinos reduced the eye and forebrain markers Xrx-1, Xpax-6, and XBF-1, while the Xpygo-2alpha morpholino also eliminated expression of the mid-hindbrain marker En-2. The differential expression and regulatory activities of Xpygo-2alpha/beta in rostral neural tissue indicate that they represent essential components of a novel mechanism for Wnt signaling in regionalization of the brain." @default.
- W2025707029 created "2016-06-24" @default.
- W2025707029 creator A5033111028 @default.
- W2025707029 creator A5037491717 @default.
- W2025707029 date "2003-09-01" @default.
- W2025707029 modified "2023-09-23" @default.
- W2025707029 title "Pygopus is required for embryonic brain patterning in Xenopus" @default.
- W2025707029 cites W1469313314 @default.
- W2025707029 cites W1500827124 @default.
- W2025707029 cites W1504655784 @default.
- W2025707029 cites W1511545125 @default.
- W2025707029 cites W1559690534 @default.
- W2025707029 cites W1563545224 @default.
- W2025707029 cites W1564357553 @default.
- W2025707029 cites W1589588578 @default.
- W2025707029 cites W1607619176 @default.
- W2025707029 cites W1611720630 @default.
- W2025707029 cites W1635607892 @default.
- W2025707029 cites W1659265739 @default.
- W2025707029 cites W1762303456 @default.
- W2025707029 cites W1868158025 @default.
- W2025707029 cites W1920180838 @default.
- W2025707029 cites W1920825899 @default.
- W2025707029 cites W1926770385 @default.
- W2025707029 cites W1944789371 @default.
- W2025707029 cites W1968877222 @default.
- W2025707029 cites W1968926070 @default.
- W2025707029 cites W1971249668 @default.
- W2025707029 cites W1971906974 @default.
- W2025707029 cites W1974005072 @default.
- W2025707029 cites W1974160989 @default.
- W2025707029 cites W1974832763 @default.
- W2025707029 cites W1975853332 @default.
- W2025707029 cites W1976353556 @default.
- W2025707029 cites W1977814055 @default.
- W2025707029 cites W1980955976 @default.
- W2025707029 cites W1987938190 @default.
- W2025707029 cites W1989194294 @default.
- W2025707029 cites W1989215255 @default.
- W2025707029 cites W1990202320 @default.
- W2025707029 cites W1992430047 @default.
- W2025707029 cites W1992465003 @default.
- W2025707029 cites W1995337962 @default.
- W2025707029 cites W1997372859 @default.
- W2025707029 cites W1999536218 @default.
- W2025707029 cites W2001191970 @default.
- W2025707029 cites W2001835391 @default.
- W2025707029 cites W2004705005 @default.
- W2025707029 cites W2007215839 @default.
- W2025707029 cites W2011842366 @default.
- W2025707029 cites W2012092107 @default.
- W2025707029 cites W2012094424 @default.
- W2025707029 cites W2013746488 @default.
- W2025707029 cites W2013927471 @default.
- W2025707029 cites W2017668082 @default.
- W2025707029 cites W2018499493 @default.
- W2025707029 cites W2023099007 @default.
- W2025707029 cites W2024490391 @default.
- W2025707029 cites W2024727887 @default.
- W2025707029 cites W2026112588 @default.
- W2025707029 cites W2028174267 @default.
- W2025707029 cites W2030491643 @default.
- W2025707029 cites W2030712054 @default.
- W2025707029 cites W2033418096 @default.
- W2025707029 cites W2042824325 @default.
- W2025707029 cites W2047063509 @default.
- W2025707029 cites W2049563467 @default.
- W2025707029 cites W2050414776 @default.
- W2025707029 cites W2056258547 @default.
- W2025707029 cites W2057229086 @default.
- W2025707029 cites W2057972760 @default.
- W2025707029 cites W2059610930 @default.
- W2025707029 cites W2068789738 @default.
- W2025707029 cites W2068807517 @default.
- W2025707029 cites W2071397057 @default.
- W2025707029 cites W2076073895 @default.
- W2025707029 cites W2080719784 @default.
- W2025707029 cites W2081253307 @default.
- W2025707029 cites W2083061238 @default.
- W2025707029 cites W2083959249 @default.
- W2025707029 cites W2084457045 @default.
- W2025707029 cites W2084771679 @default.
- W2025707029 cites W2086533520 @default.
- W2025707029 cites W2090636859 @default.
- W2025707029 cites W2090851532 @default.
- W2025707029 cites W2091637225 @default.
- W2025707029 cites W2092977027 @default.
- W2025707029 cites W2097806230 @default.
- W2025707029 cites W2098387982 @default.
- W2025707029 cites W2100070586 @default.
- W2025707029 cites W2101436494 @default.
- W2025707029 cites W2102320669 @default.
- W2025707029 cites W2102512027 @default.
- W2025707029 cites W2102735467 @default.
- W2025707029 cites W2106236683 @default.
- W2025707029 cites W2112406299 @default.
- W2025707029 cites W2114511731 @default.
- W2025707029 cites W2115675121 @default.