Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025707923> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2025707923 endingPage "522" @default.
- W2025707923 startingPage "518" @default.
- W2025707923 abstract "Abstract Glomerular mesangial cells are known to express angiotensin II type 1 receptors and contract in response to circulating and/or locally produced angiotensin II. In addition, stimulation of mesangial cell matrix protein synthesis by elevated levels of angiotensin II is known to contribute to the development of glomerulosclerosis. Previously, we reported that mesangial cells were positively immunostained with antiserum directed against aminopeptidase A, the principal angiotensinase in the metabolism of angiotensin II. Here we demonstrate directly that aminopeptidase A is expressed in mesangial cells cultured from rat kidney. First, cultured mesangial cells had measurable aminopeptidase A enzymatic activity. Second, immunoblots for aminopeptidase A were positive for isolated glomeruli and mesangial cells, although two bands were seen for mesangial cells (≈138 and 144 kD), and only the larger band was seen for isolated glomeruli and kidney. Third, Northern blot hybridizations of total RNA from mesangial cells or kidney were positive and labeled similarly sized bands. Fourth, reverse transcription–polymerase chain reaction amplification of mesangial cell total RNA yielded a partial cDNA of the expected size that was confirmed by sequencing to be identical to rat kidney aminopeptidase A. These results indicate that aminopeptidase A is expressed within mesangial cells. These results further suggest that metabolism of angiotensin II by aminopeptidase A could play a protective role in minimizing the adverse effects of angiotensin II stimulation of mesangial cells." @default.
- W2025707923 created "2016-06-24" @default.
- W2025707923 creator A5010536298 @default.
- W2025707923 creator A5036286368 @default.
- W2025707923 creator A5055367672 @default.
- W2025707923 creator A5086441246 @default.
- W2025707923 date "1996-03-01" @default.
- W2025707923 modified "2023-09-23" @default.
- W2025707923 title "Expression of Aminopeptidase A, an Angiotensinase, in Glomerular Mesangial Cells" @default.
- W2025707923 cites W143205812 @default.
- W2025707923 cites W1964700899 @default.
- W2025707923 cites W1970084507 @default.
- W2025707923 cites W1973665038 @default.
- W2025707923 cites W1978799672 @default.
- W2025707923 cites W1991333202 @default.
- W2025707923 cites W2021789266 @default.
- W2025707923 cites W2031534703 @default.
- W2025707923 cites W2058713776 @default.
- W2025707923 cites W2065529409 @default.
- W2025707923 cites W2068124429 @default.
- W2025707923 cites W2070497571 @default.
- W2025707923 cites W2080883395 @default.
- W2025707923 cites W2082492249 @default.
- W2025707923 cites W2083748022 @default.
- W2025707923 cites W2093593621 @default.
- W2025707923 cites W2094618026 @default.
- W2025707923 cites W2136898798 @default.
- W2025707923 cites W397833519 @default.
- W2025707923 cites W4294216491 @default.
- W2025707923 doi "https://doi.org/10.1161/01.hyp.27.3.518" @default.
- W2025707923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8613196" @default.
- W2025707923 hasPublicationYear "1996" @default.
- W2025707923 type Work @default.
- W2025707923 sameAs 2025707923 @default.
- W2025707923 citedByCount "15" @default.
- W2025707923 countsByYear W20257079232014 @default.
- W2025707923 countsByYear W20257079232015 @default.
- W2025707923 countsByYear W20257079232019 @default.
- W2025707923 crossrefType "journal-article" @default.
- W2025707923 hasAuthorship W2025707923A5010536298 @default.
- W2025707923 hasAuthorship W2025707923A5036286368 @default.
- W2025707923 hasAuthorship W2025707923A5055367672 @default.
- W2025707923 hasAuthorship W2025707923A5086441246 @default.
- W2025707923 hasConcept C126322002 @default.
- W2025707923 hasConcept C134018914 @default.
- W2025707923 hasConcept C153911025 @default.
- W2025707923 hasConcept C170493617 @default.
- W2025707923 hasConcept C198710026 @default.
- W2025707923 hasConcept C2776580952 @default.
- W2025707923 hasConcept C2779131090 @default.
- W2025707923 hasConcept C2779937669 @default.
- W2025707923 hasConcept C2780091579 @default.
- W2025707923 hasConcept C2780368995 @default.
- W2025707923 hasConcept C2780985610 @default.
- W2025707923 hasConcept C2908929049 @default.
- W2025707923 hasConcept C515207424 @default.
- W2025707923 hasConcept C55493867 @default.
- W2025707923 hasConcept C71924100 @default.
- W2025707923 hasConcept C84393581 @default.
- W2025707923 hasConcept C86803240 @default.
- W2025707923 hasConceptScore W2025707923C126322002 @default.
- W2025707923 hasConceptScore W2025707923C134018914 @default.
- W2025707923 hasConceptScore W2025707923C153911025 @default.
- W2025707923 hasConceptScore W2025707923C170493617 @default.
- W2025707923 hasConceptScore W2025707923C198710026 @default.
- W2025707923 hasConceptScore W2025707923C2776580952 @default.
- W2025707923 hasConceptScore W2025707923C2779131090 @default.
- W2025707923 hasConceptScore W2025707923C2779937669 @default.
- W2025707923 hasConceptScore W2025707923C2780091579 @default.
- W2025707923 hasConceptScore W2025707923C2780368995 @default.
- W2025707923 hasConceptScore W2025707923C2780985610 @default.
- W2025707923 hasConceptScore W2025707923C2908929049 @default.
- W2025707923 hasConceptScore W2025707923C515207424 @default.
- W2025707923 hasConceptScore W2025707923C55493867 @default.
- W2025707923 hasConceptScore W2025707923C71924100 @default.
- W2025707923 hasConceptScore W2025707923C84393581 @default.
- W2025707923 hasConceptScore W2025707923C86803240 @default.
- W2025707923 hasIssue "3" @default.
- W2025707923 hasLocation W20257079231 @default.
- W2025707923 hasLocation W20257079232 @default.
- W2025707923 hasOpenAccess W2025707923 @default.
- W2025707923 hasPrimaryLocation W20257079231 @default.
- W2025707923 hasRelatedWork W1992220075 @default.
- W2025707923 hasRelatedWork W2024736606 @default.
- W2025707923 hasRelatedWork W2042660006 @default.
- W2025707923 hasRelatedWork W2077998387 @default.
- W2025707923 hasRelatedWork W2126797993 @default.
- W2025707923 hasRelatedWork W2133339247 @default.
- W2025707923 hasRelatedWork W2149410839 @default.
- W2025707923 hasRelatedWork W2151139437 @default.
- W2025707923 hasRelatedWork W2190649397 @default.
- W2025707923 hasRelatedWork W2744890335 @default.
- W2025707923 hasVolume "27" @default.
- W2025707923 isParatext "false" @default.
- W2025707923 isRetracted "false" @default.
- W2025707923 magId "2025707923" @default.
- W2025707923 workType "article" @default.