Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025710366> ?p ?o ?g. }
- W2025710366 endingPage "120" @default.
- W2025710366 startingPage "109" @default.
- W2025710366 abstract "MUC1, a tumor-associated antigen overexpressed in many carcinomas, represents a candidate of choice for cancer immunotherapy. Flagella-based MUC1 vaccines were tested in therapeutic setting in two aggressive breast cancer models, comprising the implantation of the 4T1-MUC1 cell line in either Balb/c, or Human MUC1 transgenic mice in which spontaneous metastases occurs. Recombinant flagella carrying only 7 amino acid of MUC1 elicited therapeutic activity, affecting both the growth of established growing tumors and the number of metastases. Higher therapeutic activity was achieved with an additional recombinant flagella designed with the SYFPEITHI algorithm. The vaccines triggered a Th1 response against MUC1 with no evident autoimmune response towards healthy MUC1-expressing tissues. Recombinant flagella carrying a 25-residue fragment of MUC1, induced the most effective response, as evidenced by a significant reduction of both the size and growth rate of the tumor as well as by the lower number of metastases, and expanding life span of vaccinated mice." @default.
- W2025710366 created "2016-06-24" @default.
- W2025710366 creator A5033480661 @default.
- W2025710366 creator A5091113056 @default.
- W2025710366 date "2012-01-01" @default.
- W2025710366 modified "2023-10-01" @default.
- W2025710366 title "Therapeutic MUC1-Based Cancer Vaccine Expressed in Flagella-Efficacy in an Aggressive Model of Breast Cancer" @default.
- W2025710366 cites W1915721030 @default.
- W2025710366 cites W1918530663 @default.
- W2025710366 cites W1982802162 @default.
- W2025710366 cites W1987016144 @default.
- W2025710366 cites W1989660541 @default.
- W2025710366 cites W1994048581 @default.
- W2025710366 cites W1998641031 @default.
- W2025710366 cites W2001740313 @default.
- W2025710366 cites W2005265786 @default.
- W2025710366 cites W2007497663 @default.
- W2025710366 cites W2014428384 @default.
- W2025710366 cites W2022890571 @default.
- W2025710366 cites W2042134605 @default.
- W2025710366 cites W2044567178 @default.
- W2025710366 cites W2054083925 @default.
- W2025710366 cites W2067541106 @default.
- W2025710366 cites W2081937540 @default.
- W2025710366 cites W2111912457 @default.
- W2025710366 cites W2126500509 @default.
- W2025710366 cites W2126953691 @default.
- W2025710366 cites W2137466010 @default.
- W2025710366 cites W2146674901 @default.
- W2025710366 cites W2147154643 @default.
- W2025710366 cites W2152351571 @default.
- W2025710366 cites W2155312231 @default.
- W2025710366 cites W2163451350 @default.
- W2025710366 cites W2171617845 @default.
- W2025710366 doi "https://doi.org/10.4236/wjv.2012.23015" @default.
- W2025710366 hasPublicationYear "2012" @default.
- W2025710366 type Work @default.
- W2025710366 sameAs 2025710366 @default.
- W2025710366 citedByCount "7" @default.
- W2025710366 countsByYear W20257103662014 @default.
- W2025710366 countsByYear W20257103662015 @default.
- W2025710366 countsByYear W20257103662017 @default.
- W2025710366 countsByYear W20257103662018 @default.
- W2025710366 countsByYear W20257103662020 @default.
- W2025710366 crossrefType "journal-article" @default.
- W2025710366 hasAuthorship W2025710366A5033480661 @default.
- W2025710366 hasAuthorship W2025710366A5091113056 @default.
- W2025710366 hasBestOaLocation W20257103661 @default.
- W2025710366 hasConcept C104317684 @default.
- W2025710366 hasConcept C115811362 @default.
- W2025710366 hasConcept C121608353 @default.
- W2025710366 hasConcept C126322002 @default.
- W2025710366 hasConcept C147483822 @default.
- W2025710366 hasConcept C203014093 @default.
- W2025710366 hasConcept C2777421810 @default.
- W2025710366 hasConcept C2777701055 @default.
- W2025710366 hasConcept C2778378633 @default.
- W2025710366 hasConcept C2780674031 @default.
- W2025710366 hasConcept C40767141 @default.
- W2025710366 hasConcept C502942594 @default.
- W2025710366 hasConcept C530470458 @default.
- W2025710366 hasConcept C55493867 @default.
- W2025710366 hasConcept C71924100 @default.
- W2025710366 hasConcept C86803240 @default.
- W2025710366 hasConceptScore W2025710366C104317684 @default.
- W2025710366 hasConceptScore W2025710366C115811362 @default.
- W2025710366 hasConceptScore W2025710366C121608353 @default.
- W2025710366 hasConceptScore W2025710366C126322002 @default.
- W2025710366 hasConceptScore W2025710366C147483822 @default.
- W2025710366 hasConceptScore W2025710366C203014093 @default.
- W2025710366 hasConceptScore W2025710366C2777421810 @default.
- W2025710366 hasConceptScore W2025710366C2777701055 @default.
- W2025710366 hasConceptScore W2025710366C2778378633 @default.
- W2025710366 hasConceptScore W2025710366C2780674031 @default.
- W2025710366 hasConceptScore W2025710366C40767141 @default.
- W2025710366 hasConceptScore W2025710366C502942594 @default.
- W2025710366 hasConceptScore W2025710366C530470458 @default.
- W2025710366 hasConceptScore W2025710366C55493867 @default.
- W2025710366 hasConceptScore W2025710366C71924100 @default.
- W2025710366 hasConceptScore W2025710366C86803240 @default.
- W2025710366 hasIssue "03" @default.
- W2025710366 hasLocation W20257103661 @default.
- W2025710366 hasOpenAccess W2025710366 @default.
- W2025710366 hasPrimaryLocation W20257103661 @default.
- W2025710366 hasRelatedWork W1524893365 @default.
- W2025710366 hasRelatedWork W1999014818 @default.
- W2025710366 hasRelatedWork W2004039943 @default.
- W2025710366 hasRelatedWork W2018839593 @default.
- W2025710366 hasRelatedWork W2019775514 @default.
- W2025710366 hasRelatedWork W2357650375 @default.
- W2025710366 hasRelatedWork W2362341771 @default.
- W2025710366 hasRelatedWork W2495094793 @default.
- W2025710366 hasRelatedWork W3158852109 @default.
- W2025710366 hasRelatedWork W4310278132 @default.
- W2025710366 hasVolume "02" @default.
- W2025710366 isParatext "false" @default.
- W2025710366 isRetracted "false" @default.
- W2025710366 magId "2025710366" @default.