FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025713628> ?p ?o ?g. }

• W2025713628 endingPage "914" @default.
• W2025713628 startingPage "905" @default.
• W2025713628 abstract "Caspase-3 activity has been described to be essential for drug-induced apoptosis. Recent results suggest that in addition to its downstream executor function, caspase-3 is also involved in the processing of upstream caspase-8 and -9. To test the absolute requirement for caspase-3, we examined mitomycin C (MMC)-induced apoptosis in the caspase-3 deficient human breast cancer cell line MCF-7. MMC was used as anticancer drug since this agent was preferentially active compared to chemotherapeutic compounds with differing mechanisms of action such as cisplatin, docetaxel, or lovastatin. MMC treatment led to pronounced caspase-8, -9, and -7 processing and early morphological features of apoptosis within 48 h. This could be inhibited by the broad-spectrum caspase inhibitor z-VAD.fmk and to a lesser extent by z-IETD.fmk and z-LEHD.fmk, which have a certain preference for inhibiting caspase-8 and -9, respectively. MMC induced apoptosis in MCF-7 cells was not mediated by the death receptor pathway as demonstrated by experiments using the inhibiting anti-Fas antibody ZB4 and transfections with CrmA, a viral serpin inhibitor of caspase-8, and the dominant negative Fas-associated death domain (FADD-DN). Stable expression with Bcl-2 significantly prevented the processing of caspase-9 but also of caspase-8 and blocked the induction of apoptosis. Thus, we provide evidence that caspase-3 activity is dispensable for MMC-induced apoptosis and for caspase-8 and -9 processing in MCF-7 cells." @default.
• W2025713628 created "2016-06-24" @default.
• W2025713628 creator A5001536238 @default.
• W2025713628 creator A5008912538 @default.
• W2025713628 creator A5079185533 @default.
• W2025713628 creator A5080987396 @default.
• W2025713628 date "2002-08-16" @default.
• W2025713628 modified "2023-10-16" @default.
• W2025713628 title "Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway" @default.
• W2025713628 cites W1497251274 @default.
• W2025713628 cites W1506642042 @default.
• W2025713628 cites W1587890084 @default.
• W2025713628 cites W1845459216 @default.
• W2025713628 cites W1935990934 @default.
• W2025713628 cites W1967912613 @default.
• W2025713628 cites W1973109581 @default.
• W2025713628 cites W1977499961 @default.
• W2025713628 cites W1978230043 @default.
• W2025713628 cites W1979444649 @default.
• W2025713628 cites W1986308149 @default.
• W2025713628 cites W1996174406 @default.
• W2025713628 cites W1996180957 @default.
• W2025713628 cites W1997005484 @default.
• W2025713628 cites W1998175560 @default.
• W2025713628 cites W2022135873 @default.
• W2025713628 cites W2032361307 @default.
• W2025713628 cites W2035153917 @default.
• W2025713628 cites W2038055601 @default.
• W2025713628 cites W2045563337 @default.
• W2025713628 cites W2048997359 @default.
• W2025713628 cites W2049110705 @default.
• W2025713628 cites W2053273074 @default.
• W2025713628 cites W2058855556 @default.
• W2025713628 cites W2061497413 @default.
• W2025713628 cites W2076317085 @default.
• W2025713628 cites W2083077527 @default.
• W2025713628 cites W2087450028 @default.
• W2025713628 cites W2092137154 @default.
• W2025713628 cites W2111650534 @default.
• W2025713628 cites W2111714805 @default.
• W2025713628 cites W2113999599 @default.
• W2025713628 cites W2115491208 @default.
• W2025713628 cites W2123945572 @default.
• W2025713628 cites W2148200419 @default.
• W2025713628 cites W2151501496 @default.
• W2025713628 cites W2156315402 @default.
• W2025713628 cites W2157999078 @default.
• W2025713628 cites W2167490100 @default.
• W2025713628 cites W2169455799 @default.
• W2025713628 cites W2319173743 @default.
• W2025713628 cites W2332144417 @default.
• W2025713628 cites W2335526988 @default.
• W2025713628 cites W4248552289 @default.
• W2025713628 doi "https://doi.org/10.1038/sj.cdd.4401062" @default.
• W2025713628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12181741" @default.
• W2025713628 hasPublicationYear "2002" @default.
• W2025713628 type Work @default.
• W2025713628 sameAs 2025713628 @default.
• W2025713628 citedByCount "138" @default.
• W2025713628 countsByYear W20257136282012 @default.
• W2025713628 countsByYear W20257136282013 @default.
• W2025713628 countsByYear W20257136282014 @default.
• W2025713628 countsByYear W20257136282015 @default.
• W2025713628 countsByYear W20257136282016 @default.
• W2025713628 countsByYear W20257136282017 @default.
• W2025713628 countsByYear W20257136282018 @default.
• W2025713628 countsByYear W20257136282019 @default.
• W2025713628 countsByYear W20257136282020 @default.
• W2025713628 countsByYear W20257136282021 @default.
• W2025713628 countsByYear W20257136282022 @default.
• W2025713628 countsByYear W20257136282023 @default.
• W2025713628 crossrefType "journal-article" @default.
• W2025713628 hasAuthorship W2025713628A5001536238 @default.
• W2025713628 hasAuthorship W2025713628A5008912538 @default.
• W2025713628 hasAuthorship W2025713628A5079185533 @default.
• W2025713628 hasAuthorship W2025713628A5080987396 @default.
• W2025713628 hasBestOaLocation W20257136281 @default.
• W2025713628 hasConcept C1186008 @default.
• W2025713628 hasConcept C12519072 @default.
• W2025713628 hasConcept C153911025 @default.
• W2025713628 hasConcept C155863897 @default.
• W2025713628 hasConcept C181199279 @default.
• W2025713628 hasConcept C182979987 @default.
• W2025713628 hasConcept C185592680 @default.
• W2025713628 hasConcept C190283241 @default.
• W2025713628 hasConcept C2775998712 @default.
• W2025713628 hasConcept C2776055636 @default.
• W2025713628 hasConcept C29311851 @default.
• W2025713628 hasConcept C31573885 @default.
• W2025713628 hasConcept C48297814 @default.
• W2025713628 hasConcept C55493867 @default.
• W2025713628 hasConcept C82381507 @default.
• W2025713628 hasConcept C86803240 @default.
• W2025713628 hasConcept C95444343 @default.
• W2025713628 hasConcept C98424977 @default.
• W2025713628 hasConceptScore W2025713628C1186008 @default.
• W2025713628 hasConceptScore W2025713628C12519072 @default.
• W2025713628 hasConceptScore W2025713628C153911025 @default.

• next