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- W2025725897 abstract "Noninvasive low-level laser devices have been introduced for therapeutic purpose in medicine. However, low-level lasercannot deliver enough photon density to expect positive therapeutic results in deep tissue layer due to light scatteringproperty in tissue. In order to overcome the limitation, this study was aimed to develop a negative pressure applied low-levellaser probe to enhance laser transmission and, therefore, photon density in soft tissue. In order to evaluate clinicalfeasibility of developed laser probe, ex-vivo experiments were performed with porcine skin samples and lasertransmissions were quantitatively measured as a function of tissue compression. The laser probe has an air suction holeto apply negative pressure to skin, a transparent plastic body to observe tissue deformation, and a small metallic opticalfiber guide to support the optical fiber when negative pressure was applied. By applying negative pressure to the laserprobe, the porcine skin under the fiber guide is compressed down and, low-level laser is emitted into the skin. Diffusionimages of laser in the skin samples were acquired with a CCD camera and analyzed. Compared to the intensity without compression, the peak intensity of laser beam profiles increased about 2~2.5 times and FWHM (Full Width at Half Maximum) decreased about 1.67~2.85 times. In addition, the peak intensity was linearly increased as a function ofcompression. In conclusion, we verified the enhancement of laser transmission and therefore, photon density in tissue byapplying negative pressure to the developed low-level laser probe and its potential for clinical usefulness." @default.
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- W2025725897 date "2009-02-12" @default.
- W2025725897 modified "2023-09-27" @default.
- W2025725897 title "A pressure controlled low-level laser probe to enhance photon density in soft tissue" @default.
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- W2025725897 doi "https://doi.org/10.1117/12.809924" @default.
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