Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025746106> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W2025746106 endingPage "1022" @default.
- W2025746106 startingPage "1015" @default.
- W2025746106 abstract "Valoron N is a compound which consists of the prodrug tilidine (CAS 20380-58-9), from which the active metabolite nortilidine is formed by demethylation in the liver, and the opiate antagonist naloxone (CAS 465-65-6), which prevents the abuse of the analgesic by opiate dependents. The pharmacokinetics of nortilidine and naloxone were studied in 18 male healthy subjects after oral application of tilidine/naloxone solution or tilidine/naloxone retard tablets, respectively. The following report gives the results on investigations of a) dose linearity after application of 25 mg, 50 mg and 100 mg Valoron N solution, b) dose equivalence of Valoron N solution (4 x 50 mg tilidine) and Valoron N retard tablets (2 x 100 mg tilidine) under steady state conditions, and c) the equivalence of different dose strengths of Valoron N retard tablets (50 mg, 100 mg, 200 mg tilidine/tablet). The results obtained in these studies demonstrate a dose linear kinetic for nortilidine after the application of 25 mg to 100 mg tilidine. Furthermore, there is dose equivalence between the tilidine/naloxone solution and tilidine/naloxone retard tablets, which permits the replacing of the solution with the retard tablets. Because of the equivalence of different dose strengths of Valoron N tablets, patients are able to exchange low dosed Valoron N retard tablets for higher-dosed ones (50 mg, 100 mg and 200 mg tilidine/tablet), if necessary. With their constant release of tilidine and the possibility for individual dosage, the retard tablets are efficient analgesics that improve pain therapy considerably for patients with chronic pain." @default.
- W2025746106 created "2016-06-24" @default.
- W2025746106 creator A5008984747 @default.
- W2025746106 creator A5015663977 @default.
- W2025746106 creator A5079016754 @default.
- W2025746106 date "2011-12-27" @default.
- W2025746106 modified "2023-09-25" @default.
- W2025746106 title "Pharmacokinetics of Nortilidine and Naloxone after Administration of Tilidine/Naloxone Solution or Tilidine/Naloxone Sustained Release Tablets" @default.
- W2025746106 doi "https://doi.org/10.1055/s-0031-1300326" @default.
- W2025746106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11148857" @default.
- W2025746106 hasPublicationYear "2011" @default.
- W2025746106 type Work @default.
- W2025746106 sameAs 2025746106 @default.
- W2025746106 citedByCount "4" @default.
- W2025746106 crossrefType "journal-article" @default.
- W2025746106 hasAuthorship W2025746106A5008984747 @default.
- W2025746106 hasAuthorship W2025746106A5015663977 @default.
- W2025746106 hasAuthorship W2025746106A5079016754 @default.
- W2025746106 hasConcept C126322002 @default.
- W2025746106 hasConcept C170493617 @default.
- W2025746106 hasConcept C2776885963 @default.
- W2025746106 hasConcept C2778140631 @default.
- W2025746106 hasConcept C2778750930 @default.
- W2025746106 hasConcept C71924100 @default.
- W2025746106 hasConcept C98274493 @default.
- W2025746106 hasConceptScore W2025746106C126322002 @default.
- W2025746106 hasConceptScore W2025746106C170493617 @default.
- W2025746106 hasConceptScore W2025746106C2776885963 @default.
- W2025746106 hasConceptScore W2025746106C2778140631 @default.
- W2025746106 hasConceptScore W2025746106C2778750930 @default.
- W2025746106 hasConceptScore W2025746106C71924100 @default.
- W2025746106 hasConceptScore W2025746106C98274493 @default.
- W2025746106 hasIssue "11" @default.
- W2025746106 hasLocation W20257461061 @default.
- W2025746106 hasLocation W20257461062 @default.
- W2025746106 hasOpenAccess W2025746106 @default.
- W2025746106 hasPrimaryLocation W20257461061 @default.
- W2025746106 hasRelatedWork W1977211513 @default.
- W2025746106 hasRelatedWork W1996983763 @default.
- W2025746106 hasRelatedWork W2002228438 @default.
- W2025746106 hasRelatedWork W2003027046 @default.
- W2025746106 hasRelatedWork W2034575949 @default.
- W2025746106 hasRelatedWork W2088180980 @default.
- W2025746106 hasRelatedWork W2271526865 @default.
- W2025746106 hasRelatedWork W2592024977 @default.
- W2025746106 hasRelatedWork W2041506595 @default.
- W2025746106 hasRelatedWork W2407702514 @default.
- W2025746106 hasVolume "50" @default.
- W2025746106 isParatext "false" @default.
- W2025746106 isRetracted "false" @default.
- W2025746106 magId "2025746106" @default.
- W2025746106 workType "article" @default.