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- W2025748905 abstract "The Fundulus spawning reflex activity of the teleostean neurohypophysial peptides, arginine vasotocin (AVT) and isotocin (IT), was assayed by criteria specified in earlier investigations. One Fundulus unit is contained in 47–62.5 ng/g of AVT, but a 10-fold larger dose of IT is required, 480–790 ng/g. The effective dose of AVT is similar to that reported for arginine vasopressin (AVP), 53 ng/g. Oxytocin (OT) requires a somewhat larger dose, ca. 100 ng/g, but it is nevertheless more active than the corresponding teleostean peptide, IT. Vasopressor activity was considered as a possible common denominator in the spawning reflex activity of the basic peptides, AVT and AVP, but negative results are reported for other teleostean vasoactive agents: catecholamines, angiotensin II and an extract of Gillichthys urophysis. The response is specific to neurohypophysial peptides, but the long latency and pharmacological nature of the effective dose present as yet unresolved problems." @default.
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- W2025748905 date "1977-06-01" @default.
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- W2025748905 title "The spawning reflex response of the killifish, Fundulus heteroclitus: Isotocin is relatively inactive in comparison with arginine vasotocin" @default.
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- W2025748905 doi "https://doi.org/10.1016/0016-6480(77)90143-5" @default.
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