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• W2025749480 abstract "Abstract TRAIL and agonistic antibodies raised against TRAIL death receptors are highly promising new anticancer agents. In this brief review, we describe the recent advances in the molecular understanding of TRAIL signaling and the progress made in using TRAIL or agonistic antibodies clinically in mono- and combination therapies. Synergies have been reported in various scenarios of TRAIL-based multidrug treatments, and these can be used to potentiate the efficacy of therapies targeting TRAIL death receptors. We pay particular attention to structure the current knowledge on the diverse molecular mechanisms that are thought to give rise to these synergies and describe how different signaling features evoking synergies can be associated with distinct classes of drugs used in TRAIL-based combination treatments. Mol Cancer Ther; 11(1); 3–13. ©2012 AACR." @default.
• W2025749480 created "2016-06-24" @default.
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• W2025749480 date "2012-01-01" @default.
• W2025749480 modified "2023-10-03" @default.
• W2025749480 title "TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies" @default.
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• W2025749480 doi "https://doi.org/10.1158/1535-7163.mct-11-0434" @default.
• W2025749480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22234808" @default.
• W2025749480 hasPublicationYear "2012" @default.
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