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- W2025755721 abstract "Tritium labeled isotopomers of (2S,3R)-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]-2-hydroxypropionic acid (SK&F 104353) with high specific activity were prepared by catalytic tritiation of the corresponding halogenated and unsaturated precursors. These precursors were synthesized from their respective benzaldehydes using a core sequence (Darzens Condensation, epoxide opening and base-induced retroaldol reaction) to generate the required alpha-hydroxy propionic acid moiety. Upon tritiation, the halogenated substrate provided the dimethyl ester derivative having a specific activity of 55 Ci/mmol, while the unsaturated precursor led directly to [3H]SK&F 104353 with a specific activity of 138 Ci/mmole." @default.
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- W2025755721 date "1990-02-01" @default.
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- W2025755721 title "Synthesis of tritiated leukotriene antagonist SK&F 104353" @default.
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- W2025755721 doi "https://doi.org/10.1002/jlcr.2580280213" @default.
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