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- W2025757577 abstract "Because creatine kinase (CK)* the heart is found primarily myocardial cells themselves, it is not surprising that cardiac CK depletion after coronary occlusion correlates with gross, 1 microscopic and ultrastructural criteria of infarction, 2 regional ischemia detected with microspheres, 1,3 depressed free fatty acid accumulation 4 and altered attenuation of ultrasound. 5 Accordingly, estimation of CK depletion from plasma CK time-activity curves appeared to be potentially useful, and a simple model was developed which serial plasma CK changes were attributed to release of CK from the heart and first order disappearance from blood.6. 7 Despite obvious imperfections, enzymatic estimates of infarct size studies from several centers have correlated with biochemical and morphologic analyses of the heart experimental animals 6-9 and morbidity, mortality 1°-12 and histochemical assessment of necrosis patients. 13 Estimates have been improved by quantifying MB CK, TM an isoenzyme man virtually confined to myocardium. Further improvements should result from characterization of mechanisms responsible for kinetics of CK the circulation. 15 Although plasma time-activity curves have been considered from a theoretical point of view, TM inadequate attention has been devoted to the quality of the data. One important source of error is sampling technique. Since skeletal muscle contains more than 3,000 IU/g, and plasma CK activity is approximately 0.1 to 1.5 IU/ml, even minor trauma to muscle near the sampling site will greatly distort results. 17 Accordingly, plasma CK time-activity curves should not be performed after surgery experimental animals until values have returned to control levels, repetitive venipuncture should be avoided and plasma samples should be collected after thorough washout of dead space in catheters to assure reproducibility. Neglect of these precautions leads to" @default.
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- W2025757577 date "1977-01-01" @default.
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- W2025757577 title "Factors influencing enzymatic estimates of infarct size" @default.
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- W2025757577 doi "https://doi.org/10.1016/s0002-9149(77)80024-6" @default.
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