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• W2025761505 abstract "Background Inflammatory airway disease ( IAD ) affects performance and well‐being of horses. Diagnosis is primarily reached by bronchoalveolar lavage ( BAL ) cytology which is invasive and requires sedation. Objectives The purpose of this study was to identify differential gene expression in peripheral blood of horses with IAD using species‐specific expression microarrays. Methods Equine gene expression microarrays were used to investigate global mRNA expression in circulating leukocytes from healthy, IAD‐affected, and low‐performing Standardbred and endurance horses. Results Nine genes in Standardbred and 61 genes in endurance horses were significantly differentially regulated ( P < .001). These genes were related to inflammation (eg, ALOX15B , PLA2G12B , and PENK ), oxidant/antioxidant balance (eg, DUOXA2 and GSTO1‐1 ), and stress (eg, V1aR, GRLF1 , Homer‐2 , and MAOB ). All these genes were up‐regulated, except down‐regulated Homer‐2 and MAOB. DUOXA2 , ALOX15B , PLA2G12B, MAOB , and GRLF1 expression was further validated by RT‐ qPCR . An increase in glutathione peroxidase (GPx) activity in heparinized whole blood of IAD‐affected Standardbred ( P = .0025) and endurance horses ( P = .0028) also suggests a deregulation of the oxidant/antioxidant balance. There was good correlation ( r = .7354) between BAL neutrophil percentage and whole blood GPx activity in all horses. Conclusions This study showed that circulating blood cell gene expression reflects inflammatory responses in tissues. Whether any of the genes have potential for diagnostic applications in the future remains to be investigated. Although not specific for IAD , whole blood GP x activity appears to be correlated with BAL neutrophil percentage. This finding should be further assessed by testing a larger number of horses." @default.
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• W2025761505 date "2014-12-08" @default.
• W2025761505 modified "2023-10-03" @default.
• W2025761505 title "Expression microarray as a tool to identify differentially expressed genes in horses suffering from inflammatory airway disease" @default.
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• W2025761505 doi "https://doi.org/10.1111/vcp.12216" @default.
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