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• W2025771220 abstract "The surface of developing axons expands in a process mediated by the exocyst complex. The spatio-temporal regulation of the exocyst is only partially understood. Here we report that stimulated membrane enlargement in dorsal root ganglion (DRG) axons is triggered by intra-axonal synthesis of TC10, a small GTPase required for exocyst function. Induced membrane expansion and axon outgrowth are inhibited after axon-specific knockdown of TC10 mRNA. To determine the relationship of intra-axonal TC10 synthesis with the previously described stimulus-induced translation of the cytoskeletal regulator Par3, we investigate the signalling pathways controlling their local translation in response to NGF. Phosphoinositide 3-kinase (PI3K)-dependent activation of the Rheb-mTOR pathway triggers the simultaneous local synthesis of TC10 and Par3. These results reveal the importance of local translation in the control of membrane dynamics and demonstrate that localized, mTOR-dependent protein synthesis triggers the simultaneous activation of parallel pathways. Axon growth requires exocyst-dependent membrane expansion, however it is unclear how this process is spatially regulated. Gracias et al.show that axonal translation of the exocyst regulator TC10 is necessary for stimulated membrane growth, and propose that local translation coordinates membrane and cytoskeletal enlargement." @default.
• W2025771220 created "2016-06-24" @default.
• W2025771220 creator A5046833077 @default.
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• W2025771220 date "2014-03-25" @default.
• W2025771220 modified "2023-10-18" @default.
• W2025771220 title "Local translation of TC10 is required for membrane expansion during axon outgrowth" @default.
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• W2025771220 doi "https://doi.org/10.1038/ncomms4506" @default.
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