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- W2025778843 abstract "remission. Twenty-four of 41 (58.5%) patients needed for systemic steroids, 13/41 (31.7%) for immunosuppressive agents, 8/41 (19.5%) for biological agents and 3/41 (7.3%) required surgery. If we consider smoking status at the discontinuation of the drug, overall in 41 patients who have stopped AZA with at least one year of follow-up after withdrawal, 17/41 (41.5%) were current smokers, 18/41 (43.9%) never smokers and 6/41 (14.5%) former smokers. If we consider among these patients those who maintained remission at 1 year after withdrawal of AZA number of current smoker was greater (5/7 current smokers vs. 1/7 never smoker). This result is consistent with very recent data from literature, which suggest current smoking as a factor delaying relapse after AZA discontinuation (2). Conclusions: Our retrospective study confirms a high frequency of relapse after azathioprine discontinuation, whatever the reason and the timing of discontinuation itself. References: 1.Treton X, Bouhnik Y, Mary JY, et al. Azathioprine withdrawal in patients with Crohn’s disease maintained on prolonged remission: a high risk of relapse. Clin Gastroenterol Hepatol 2009;7:80.5. 2.Sokol H, Seksik P, NionLarmurier I, et al. Current smoking, not duration of remission, delays Crohn’s disease relapse following azathioprine withdrawal. Inflamm Bowel Dis 2009; in press (PMID: 19462422). # G. Inflammatory bowel diseases 2. Ulcerative colitis and Crohn’s disease diagnosis/therapy" @default.
- W2025778843 created "2016-06-24" @default.
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- W2025778843 date "2010-03-01" @default.
- W2025778843 modified "2023-09-27" @default.
- W2025778843 title "P.76 BECLOMETHASONE DIPROPIONATE FOR THE MAINTENANCE OF REMISSION INDUCED BY A SHORT COURSE OF SYSTEMIC STEROIDS IN CROHN'S ILEITIS: A RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PLACEBO-CONTROLLED STUDY" @default.
- W2025778843 doi "https://doi.org/10.1016/s1590-8658(10)60189-2" @default.
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