Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025783979> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2025783979 endingPage "212" @default.
- W2025783979 startingPage "211" @default.
- W2025783979 abstract "tain large amounts of substance PI’. Kevoked release of substance P has been demonstrated in several tissues including the isolated spinal cordIs. Furthermore. stimulalion of trigeminal nerves causes a netease of substance P in the dental pulp”. The functional significance of substance P is at ppsent under intensive study in several laboratories and it has been assigned a neumtransmitter or neuromodulatory mle in the CNS and in peripheral organs. substall@Psnologucsasan~ Obviously. the availability of specific substance P-antagonists would facilitate the analysis of the physiological function of substance P and also be of importance for a better understanding of the role of sub stance P in pathological conditions. Moreover, on the basis of what we knou about the distribution and effect of sub stance P, it is obvious that substance P-antagonists may fom the basis for a new type of drug. Reports on substance P antagonistic actions of various substances such as arfonad and baclofen’* have been published but subsequent studies indicate that these drugs do not block the effects of substance P specifically in all tissues. In 1975 we started a project with the aim of developing specifK substance Pantagonists on the basis of substance Panalogues. The first step was then to achieve a more or less total loss of agonist uctivity by means of structural suhstitutions. Studies with substance P (Aq’-ProiLys’ - Pm’ - Gins - Gin” - Phe’ - Pheb - Gly” Leu’“-Met”-Ntll) and smaller sequer+ ces of it revealed the imponancc of chain length and of the amino acid residues Phe’. Leu’” and Met” ft>r the smooth muAc activity of substance P. which is confined to the C-terminal hexapeptide sequence of substance P. Among scver;ll suhstanee P-analogues with low agonist activity (&Phe’)_SPand @Leu@‘. bPhe”&SPwcrc found to slightly inhibit the substance P-induced contractionof the terminal ileum <rf the guinea pig’:<“. We did not .malyse" @default.
- W2025783979 created "2016-06-24" @default.
- W2025783979 creator A5005155818 @default.
- W2025783979 creator A5091677306 @default.
- W2025783979 date "1982-01-01" @default.
- W2025783979 modified "2023-10-02" @default.
- W2025783979 title "Substance P-antagonists: a new type of pharmacological tool" @default.
- W2025783979 cites W1967927763 @default.
- W2025783979 cites W1968858188 @default.
- W2025783979 cites W1969699551 @default.
- W2025783979 cites W1971334105 @default.
- W2025783979 cites W1982230371 @default.
- W2025783979 cites W2033899257 @default.
- W2025783979 cites W2034443911 @default.
- W2025783979 cites W2046420598 @default.
- W2025783979 cites W2046645455 @default.
- W2025783979 cites W2065326514 @default.
- W2025783979 cites W2069413548 @default.
- W2025783979 cites W2086144893 @default.
- W2025783979 cites W2119079154 @default.
- W2025783979 doi "https://doi.org/10.1016/0165-6147(82)91095-1" @default.
- W2025783979 hasPublicationYear "1982" @default.
- W2025783979 type Work @default.
- W2025783979 sameAs 2025783979 @default.
- W2025783979 citedByCount "59" @default.
- W2025783979 countsByYear W20257839792017 @default.
- W2025783979 crossrefType "journal-article" @default.
- W2025783979 hasAuthorship W2025783979A5005155818 @default.
- W2025783979 hasAuthorship W2025783979A5091677306 @default.
- W2025783979 hasConcept C15744967 @default.
- W2025783979 hasConcept C542102704 @default.
- W2025783979 hasConcept C71924100 @default.
- W2025783979 hasConcept C98274493 @default.
- W2025783979 hasConceptScore W2025783979C15744967 @default.
- W2025783979 hasConceptScore W2025783979C542102704 @default.
- W2025783979 hasConceptScore W2025783979C71924100 @default.
- W2025783979 hasConceptScore W2025783979C98274493 @default.
- W2025783979 hasLocation W20257839791 @default.
- W2025783979 hasOpenAccess W2025783979 @default.
- W2025783979 hasPrimaryLocation W20257839791 @default.
- W2025783979 hasRelatedWork W1970375414 @default.
- W2025783979 hasRelatedWork W1988207302 @default.
- W2025783979 hasRelatedWork W2020885388 @default.
- W2025783979 hasRelatedWork W2044032703 @default.
- W2025783979 hasRelatedWork W2088456740 @default.
- W2025783979 hasRelatedWork W2604825721 @default.
- W2025783979 hasRelatedWork W2737909566 @default.
- W2025783979 hasRelatedWork W2748952813 @default.
- W2025783979 hasRelatedWork W2899084033 @default.
- W2025783979 hasRelatedWork W2297867960 @default.
- W2025783979 hasVolume "3" @default.
- W2025783979 isParatext "false" @default.
- W2025783979 isRetracted "false" @default.
- W2025783979 magId "2025783979" @default.
- W2025783979 workType "article" @default.