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- W2025792110 abstract "The effects of changes in metered volume and propellant vapour pressure on the deposition of a pressurized inhalation aerosol have been studied in 10 patients with obstructive airway disease. Particles of Teflon (mass median aerodynamic diameter 3.2. μm), labelled with 99Tcm, were incorporated into canisters formulated with two different metered volume sizes (25 and 50 μ1) and with two different propellant vapour pressures (374 and 502 kPa). Increasing the metered volume had no effect on the quantity of aerosol deposited in the lungs, but produced a significantly (P < 0.05) more central pattern of deposition within the bronchial tree. An increase in vapour pressvre resulted in a significant (P < 0.05) increase in whole lung deposition and a significant (P < 0.05) reduction in extrathoracic deposition. It is concluded that changes in formulation alter the deposition pattern of metered dose aerosols, and might consequently bring about changes in clinical efficacy." @default.
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- W2025792110 date "1982-08-01" @default.
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- W2025792110 title "The effects of changes in metered volume and propellant vapour pressure on the deposition of pressurized inhalation aerosols" @default.
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