FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025792310> ?p ?o ?g. }

• W2025792310 endingPage "144" @default.
• W2025792310 startingPage "139" @default.
• W2025792310 abstract "Independent deletion of the PARK2 gene and hTauVLW over-expression in mice produce mild alterations in the brain. However, the presence of both mutations in a parkin-deficient and hTauVLW double mutant mouse causes a tau neuropathology, reactive astrocytosis, and neuronal loss in the cortex and hippocampus, as well as lesions in nigrostriatal and motor neurons. Moreover, these mutants display some memory and exploratory defects that reflect a functional link between parkin and tau proteins. We have tested the motor activity and coordination of these double mutant mice to determine the effects of parkin deletion in mice over-expressing the hTauVLW transgene. While the loss of parkin alone produces increased exploration and alterations in gait and motor coordination, in hTauVLW transgenic mice the absence of parkin causes less prominent motor impairments. These effects suggest the existence of some compensatory mechanisms that are activated when the hTauVLW transgene is over-expressed in the absence of parkin. This mouse model will hopefully help to study the causes of the motor deficits associated with certain neuropathologies related to the tau and parkin proteins, and to find appropriate treatments." @default.
• W2025792310 created "2016-06-24" @default.
• W2025792310 creator A5029352978 @default.
• W2025792310 creator A5047004228 @default.
• W2025792310 creator A5063945536 @default.
• W2025792310 creator A5068109247 @default.
• W2025792310 creator A5072251183 @default.
• W2025792310 creator A5082463004 @default.
• W2025792310 creator A5089447741 @default.
• W2025792310 date "2008-12-01" @default.
• W2025792310 modified "2023-10-16" @default.
• W2025792310 title "Motor alterations are reduced in mice lacking the PARK2 gene in the presence of a human FTDP-17 mutant form of four-repeat tau" @default.
• W2025792310 cites W134764564 @default.
• W2025792310 cites W1456573927 @default.
• W2025792310 cites W1511517753 @default.
• W2025792310 cites W1550876205 @default.
• W2025792310 cites W1625241616 @default.
• W2025792310 cites W1877873625 @default.
• W2025792310 cites W1965111825 @default.
• W2025792310 cites W1965217223 @default.
• W2025792310 cites W1967464880 @default.
• W2025792310 cites W1973774127 @default.
• W2025792310 cites W1977002082 @default.
• W2025792310 cites W1987927755 @default.
• W2025792310 cites W1988457275 @default.
• W2025792310 cites W1988481439 @default.
• W2025792310 cites W1988979381 @default.
• W2025792310 cites W2009945323 @default.
• W2025792310 cites W2011339216 @default.
• W2025792310 cites W2012921227 @default.
• W2025792310 cites W2014793858 @default.
• W2025792310 cites W2023576137 @default.
• W2025792310 cites W2031852956 @default.
• W2025792310 cites W2035156043 @default.
• W2025792310 cites W2036755018 @default.
• W2025792310 cites W2046196399 @default.
• W2025792310 cites W2048677944 @default.
• W2025792310 cites W2050310121 @default.
• W2025792310 cites W2057682957 @default.
• W2025792310 cites W2058570072 @default.
• W2025792310 cites W2061076128 @default.
• W2025792310 cites W2061956914 @default.
• W2025792310 cites W2062181837 @default.
• W2025792310 cites W2067042124 @default.
• W2025792310 cites W2086051541 @default.
• W2025792310 cites W2092151532 @default.
• W2025792310 cites W2093613378 @default.
• W2025792310 cites W2100675686 @default.
• W2025792310 cites W2103829129 @default.
• W2025792310 cites W2105704879 @default.
• W2025792310 cites W2107438114 @default.
• W2025792310 cites W2107804537 @default.
• W2025792310 cites W2110888808 @default.
• W2025792310 cites W2111050644 @default.
• W2025792310 cites W2114358785 @default.
• W2025792310 cites W2116229231 @default.
• W2025792310 cites W2117335809 @default.
• W2025792310 cites W2129830770 @default.
• W2025792310 cites W2130924200 @default.
• W2025792310 cites W2133865158 @default.
• W2025792310 cites W2135661040 @default.
• W2025792310 cites W2136000143 @default.
• W2025792310 cites W2139638246 @default.
• W2025792310 cites W2156182885 @default.
• W2025792310 cites W2156998090 @default.
• W2025792310 cites W2158259597 @default.
• W2025792310 cites W2159838014 @default.
• W2025792310 cites W2168079270 @default.
• W2025792310 cites W2170725855 @default.
• W2025792310 cites W2172007938 @default.
• W2025792310 cites W2354701 @default.
• W2025792310 doi "https://doi.org/10.1016/j.jns.2008.08.013" @default.
• W2025792310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18817929" @default.
• W2025792310 hasPublicationYear "2008" @default.
• W2025792310 type Work @default.
• W2025792310 sameAs 2025792310 @default.
• W2025792310 citedByCount "4" @default.
• W2025792310 countsByYear W20257923102013 @default.
• W2025792310 countsByYear W20257923102014 @default.
• W2025792310 countsByYear W20257923102015 @default.
• W2025792310 crossrefType "journal-article" @default.
• W2025792310 hasAuthorship W2025792310A5029352978 @default.
• W2025792310 hasAuthorship W2025792310A5047004228 @default.
• W2025792310 hasAuthorship W2025792310A5063945536 @default.
• W2025792310 hasAuthorship W2025792310A5068109247 @default.
• W2025792310 hasAuthorship W2025792310A5072251183 @default.
• W2025792310 hasAuthorship W2025792310A5082463004 @default.
• W2025792310 hasAuthorship W2025792310A5089447741 @default.
• W2025792310 hasConcept C102230213 @default.
• W2025792310 hasConcept C104317684 @default.
• W2025792310 hasConcept C113062710 @default.
• W2025792310 hasConcept C126322002 @default.
• W2025792310 hasConcept C141035611 @default.
• W2025792310 hasConcept C143065580 @default.
• W2025792310 hasConcept C169760540 @default.
• W2025792310 hasConcept C2777668072 @default.
• W2025792310 hasConcept C2779134260 @default.
• W2025792310 hasConcept C2779734285 @default.

• next