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• W2025793608 startingPage "286" @default.
• W2025793608 abstract "The therapeutic agents currently used to treat schizophrenia effectively improve psychotic symptoms; however, they are limited by adverse effects and poor efficacy when negative symptoms of the illness and cognitive dysfunction are considered. While optimal pharmacotherapy would directly target the neuropathology of schizophrenia neither the underlying neurobiological substrates of the behavioral symptoms nor the cognitive deficits have been clearly established. Abnormalities in the neurotransmitters dopamine, serotonin, glutamate, and GABA are commonly implicated in schizophrenia; however, it is not uncommon for alterations in the brain cholinergic system (e.g., choline acetyltransferase, nicotinic and muscarinic acetylcholine receptors) to also be reported. Further, there is now considerable evidence in the animal literature to suggest that both first and second generation antipsychotics (when administered chronically) can alter the levels of several cholinergic markers in the brain as well as impair memory-related task performance. Given the well-established importance of central cholinergic neurons to information processing and cognition, it is important that cholinergic function in schizophrenia be further elucidated and that the mechanisms of the chronic effects of antipsychotic drugs on this important neurotransmitter system be identified. A better understanding of these mechanisms would be expected to facilitate optimal treatment strategies for schizophrenia as well as the identification of novel therapeutic targets. In this review, the following topics are discussed: 1) the central cholinergic system in schizophrenia 2) effects of antipsychotic drugs on central cholinergic neurons 3) important neurotrophins in schizophrenia, especially those that support central cholinergic neurons; 4) novel strategies to optimize the therapeutics of schizophrenia via the use of cholinergic compounds as primary (i.e., antipsychotic) treatments as well as adjunctive, pro-cognitive agents. Keywords: Acetylcholine, muscarinic, nicotinic, receptor, cognition, psychosis" @default.
• W2025793608 created "2016-06-24" @default.
• W2025793608 creator A5028964250 @default.
• W2025793608 date "2008-09-01" @default.
• W2025793608 modified "2023-10-15" @default.
• W2025793608 title "Role of the Central Cholinergic System in the Therapeutics of Schizophrenia" @default.
• W2025793608 cites W10169455 @default.
• W2025793608 cites W114047989 @default.
• W2025793608 cites W1492009115 @default.
• W2025793608 cites W152718690 @default.
• W2025793608 cites W1532317254 @default.
• W2025793608 cites W1555962635 @default.
• W2025793608 cites W1560330290 @default.
• W2025793608 cites W158488463 @default.
• W2025793608 cites W1596886387 @default.
• W2025793608 cites W1603286332 @default.
• W2025793608 cites W1947019691 @default.
• W2025793608 cites W1964316199 @default.
• W2025793608 cites W1964697111 @default.
• W2025793608 cites W1967209958 @default.
• W2025793608 cites W1967984696 @default.
• W2025793608 cites W1977755787 @default.
• W2025793608 cites W1980420785 @default.
• W2025793608 cites W1980719669 @default.
• W2025793608 cites W1991199561 @default.
• W2025793608 cites W1991647020 @default.
• W2025793608 cites W1994851210 @default.
• W2025793608 cites W1994979924 @default.
• W2025793608 cites W1996605747 @default.
• W2025793608 cites W1996729908 @default.
• W2025793608 cites W1998776530 @default.
• W2025793608 cites W1999514770 @default.
• W2025793608 cites W1999774383 @default.
• W2025793608 cites W1999965577 @default.
• W2025793608 cites W2000845566 @default.
• W2025793608 cites W2003010674 @default.
• W2025793608 cites W2004133121 @default.
• W2025793608 cites W2005044038 @default.
• W2025793608 cites W2005627203 @default.
• W2025793608 cites W2005891675 @default.
• W2025793608 cites W2009630851 @default.
• W2025793608 cites W2014204077 @default.
• W2025793608 cites W2018486737 @default.
• W2025793608 cites W2018885303 @default.
• W2025793608 cites W2019885827 @default.
• W2025793608 cites W2020358225 @default.
• W2025793608 cites W2025149917 @default.
• W2025793608 cites W2025611163 @default.
• W2025793608 cites W2027909191 @default.
• W2025793608 cites W2028747258 @default.
• W2025793608 cites W2028926425 @default.
• W2025793608 cites W2030360517 @default.
• W2025793608 cites W2030477730 @default.
• W2025793608 cites W2035249251 @default.
• W2025793608 cites W2035565264 @default.
• W2025793608 cites W2035788257 @default.
• W2025793608 cites W2036142941 @default.
• W2025793608 cites W2044662576 @default.
• W2025793608 cites W2045538158 @default.
• W2025793608 cites W2049699492 @default.
• W2025793608 cites W2052719913 @default.
• W2025793608 cites W2059495695 @default.
• W2025793608 cites W2062248450 @default.
• W2025793608 cites W2062419094 @default.
• W2025793608 cites W2063097051 @default.
• W2025793608 cites W2063849763 @default.
• W2025793608 cites W2067418199 @default.
• W2025793608 cites W2069957927 @default.
• W2025793608 cites W2073988872 @default.
• W2025793608 cites W2074620251 @default.
• W2025793608 cites W2076818678 @default.
• W2025793608 cites W2079108601 @default.
• W2025793608 cites W2079918087 @default.
• W2025793608 cites W2080108309 @default.
• W2025793608 cites W2083502141 @default.
• W2025793608 cites W2086071731 @default.
• W2025793608 cites W2091240406 @default.
• W2025793608 cites W2092446825 @default.
• W2025793608 cites W2092829073 @default.
• W2025793608 cites W2096693305 @default.
• W2025793608 cites W2097648013 @default.
• W2025793608 cites W2099515172 @default.
• W2025793608 cites W2102405317 @default.
• W2025793608 cites W2103929977 @default.
• W2025793608 cites W2109645417 @default.
• W2025793608 cites W2110569861 @default.
• W2025793608 cites W2112372880 @default.
• W2025793608 cites W2113592951 @default.
• W2025793608 cites W2113950478 @default.
• W2025793608 cites W2123596761 @default.
• W2025793608 cites W2131003664 @default.
• W2025793608 cites W2131403016 @default.
• W2025793608 cites W2132980997 @default.
• W2025793608 cites W2133666658 @default.
• W2025793608 cites W2136614794 @default.
• W2025793608 cites W2138627575 @default.
• W2025793608 cites W2139971720 @default.
• W2025793608 cites W2143920419 @default.

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