Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025794310> ?p ?o ?g. }
- W2025794310 abstract "Hyperkalemic periodic paralysis (HyperKPP) is a disease characterized by periods of myotonic discharges and paralytic attacks causing weakness, the latter associated with increases in plasma [K(+)]. The myotonic discharge is due to increased Na(+) influx through defective Na(+) channels that triggers generation of several action potentials. The subsequent increase in extracellular K(+) concentration causes excessive membrane depolarization that inactivates Na(+) channels triggering the paralysis. None of the available treatments is fully effective. This paper reviews the capacity of Na(+) K(+)ATPase pumps, KATP and ClC-1 Cl(-) channels in improving membrane excitability during muscle activity and how using these three membrane components we can study future and more effective treatments for HyperKPP patients. The review of current patents related to HyperKPP reinforces the need of novel approaches for the treatment of this channelopathy." @default.
- W2025794310 created "2016-06-24" @default.
- W2025794310 creator A5059113011 @default.
- W2025794310 creator A5090861892 @default.
- W2025794310 date "2012-11-01" @default.
- W2025794310 modified "2023-09-25" @default.
- W2025794310 title "Lessons Learned from Muscle Fatigue: Implications for Treatment of Patients with Hyperkalemic Periodic Paralysis" @default.
- W2025794310 cites W1480569731 @default.
- W2025794310 cites W1519766384 @default.
- W2025794310 cites W1549212895 @default.
- W2025794310 cites W1566472590 @default.
- W2025794310 cites W1660925261 @default.
- W2025794310 cites W1909588247 @default.
- W2025794310 cites W1927258044 @default.
- W2025794310 cites W1945029457 @default.
- W2025794310 cites W1967504931 @default.
- W2025794310 cites W1967761990 @default.
- W2025794310 cites W1973815254 @default.
- W2025794310 cites W1974752766 @default.
- W2025794310 cites W1975596541 @default.
- W2025794310 cites W1976431161 @default.
- W2025794310 cites W1983123512 @default.
- W2025794310 cites W1985940938 @default.
- W2025794310 cites W1992383893 @default.
- W2025794310 cites W1995134770 @default.
- W2025794310 cites W1998006950 @default.
- W2025794310 cites W1998529806 @default.
- W2025794310 cites W2000571335 @default.
- W2025794310 cites W2008087877 @default.
- W2025794310 cites W2008364772 @default.
- W2025794310 cites W2011055224 @default.
- W2025794310 cites W2015122598 @default.
- W2025794310 cites W2018594405 @default.
- W2025794310 cites W2022165197 @default.
- W2025794310 cites W2032105509 @default.
- W2025794310 cites W2035223763 @default.
- W2025794310 cites W2037962705 @default.
- W2025794310 cites W2039932050 @default.
- W2025794310 cites W2046572231 @default.
- W2025794310 cites W2048782618 @default.
- W2025794310 cites W2049251974 @default.
- W2025794310 cites W2054630465 @default.
- W2025794310 cites W2055468934 @default.
- W2025794310 cites W2055933325 @default.
- W2025794310 cites W2058847522 @default.
- W2025794310 cites W2060126253 @default.
- W2025794310 cites W2061165996 @default.
- W2025794310 cites W2062522382 @default.
- W2025794310 cites W2064432726 @default.
- W2025794310 cites W2064953660 @default.
- W2025794310 cites W2065857917 @default.
- W2025794310 cites W2066603791 @default.
- W2025794310 cites W2067312729 @default.
- W2025794310 cites W2078421703 @default.
- W2025794310 cites W2081834777 @default.
- W2025794310 cites W2084235009 @default.
- W2025794310 cites W2088914168 @default.
- W2025794310 cites W2095332486 @default.
- W2025794310 cites W2095342509 @default.
- W2025794310 cites W2096456978 @default.
- W2025794310 cites W2098456244 @default.
- W2025794310 cites W2099334940 @default.
- W2025794310 cites W2107632033 @default.
- W2025794310 cites W2117372087 @default.
- W2025794310 cites W2121135722 @default.
- W2025794310 cites W2123644288 @default.
- W2025794310 cites W2124008559 @default.
- W2025794310 cites W2135951481 @default.
- W2025794310 cites W2140604902 @default.
- W2025794310 cites W2141632757 @default.
- W2025794310 cites W2151308803 @default.
- W2025794310 cites W2157641845 @default.
- W2025794310 cites W2163151214 @default.
- W2025794310 cites W2170154282 @default.
- W2025794310 cites W2180395091 @default.
- W2025794310 cites W2183807052 @default.
- W2025794310 cites W2411716479 @default.
- W2025794310 cites W2417651328 @default.
- W2025794310 cites W2428712921 @default.
- W2025794310 cites W3146417683 @default.
- W2025794310 doi "https://doi.org/10.2174/1872208311206030184" @default.
- W2025794310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23092434" @default.
- W2025794310 hasPublicationYear "2012" @default.
- W2025794310 type Work @default.
- W2025794310 sameAs 2025794310 @default.
- W2025794310 citedByCount "0" @default.
- W2025794310 crossrefType "journal-article" @default.
- W2025794310 hasAuthorship W2025794310A5059113011 @default.
- W2025794310 hasAuthorship W2025794310A5090861892 @default.
- W2025794310 hasConcept C126322002 @default.
- W2025794310 hasConcept C141071460 @default.
- W2025794310 hasConcept C2776418732 @default.
- W2025794310 hasConcept C2776532573 @default.
- W2025794310 hasConcept C2777989426 @default.
- W2025794310 hasConcept C2778242168 @default.
- W2025794310 hasConcept C2779618896 @default.
- W2025794310 hasConcept C2780243291 @default.
- W2025794310 hasConcept C2781079590 @default.
- W2025794310 hasConcept C4141045 @default.
- W2025794310 hasConcept C42219234 @default.