Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025801301> ?p ?o ?g. }
- W2025801301 endingPage "76" @default.
- W2025801301 startingPage "66" @default.
- W2025801301 abstract "Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1–NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1–NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1–NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1–NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases." @default.
- W2025801301 created "2016-06-24" @default.
- W2025801301 creator A5053871848 @default.
- W2025801301 creator A5072089972 @default.
- W2025801301 date "2010-04-01" @default.
- W2025801301 modified "2023-10-03" @default.
- W2025801301 title "Targeting NRF2 signaling for cancer chemoprevention" @default.
- W2025801301 cites W1507824494 @default.
- W2025801301 cites W1508786321 @default.
- W2025801301 cites W1511492934 @default.
- W2025801301 cites W1533811499 @default.
- W2025801301 cites W1858268805 @default.
- W2025801301 cites W1965037168 @default.
- W2025801301 cites W1967077010 @default.
- W2025801301 cites W1967108243 @default.
- W2025801301 cites W1967358359 @default.
- W2025801301 cites W1967692811 @default.
- W2025801301 cites W1967914030 @default.
- W2025801301 cites W1971090593 @default.
- W2025801301 cites W1972439337 @default.
- W2025801301 cites W1972793256 @default.
- W2025801301 cites W1973882427 @default.
- W2025801301 cites W1974546855 @default.
- W2025801301 cites W1975512386 @default.
- W2025801301 cites W1977422169 @default.
- W2025801301 cites W1977501799 @default.
- W2025801301 cites W1978052764 @default.
- W2025801301 cites W1985385055 @default.
- W2025801301 cites W1987857240 @default.
- W2025801301 cites W1991631628 @default.
- W2025801301 cites W1996038316 @default.
- W2025801301 cites W1998128080 @default.
- W2025801301 cites W1998560601 @default.
- W2025801301 cites W1999872962 @default.
- W2025801301 cites W2002801265 @default.
- W2025801301 cites W2002831133 @default.
- W2025801301 cites W2003178930 @default.
- W2025801301 cites W2004288386 @default.
- W2025801301 cites W2004856155 @default.
- W2025801301 cites W2005039507 @default.
- W2025801301 cites W2008150054 @default.
- W2025801301 cites W2011388680 @default.
- W2025801301 cites W2012948713 @default.
- W2025801301 cites W2013654121 @default.
- W2025801301 cites W2015243552 @default.
- W2025801301 cites W2016603108 @default.
- W2025801301 cites W2019179222 @default.
- W2025801301 cites W2024289938 @default.
- W2025801301 cites W2028741702 @default.
- W2025801301 cites W2029022033 @default.
- W2025801301 cites W2029735473 @default.
- W2025801301 cites W2030867249 @default.
- W2025801301 cites W2031403700 @default.
- W2025801301 cites W2033274952 @default.
- W2025801301 cites W2037691927 @default.
- W2025801301 cites W2038376109 @default.
- W2025801301 cites W2038500334 @default.
- W2025801301 cites W2040898650 @default.
- W2025801301 cites W2041647205 @default.
- W2025801301 cites W2047028713 @default.
- W2025801301 cites W2049540980 @default.
- W2025801301 cites W2050599166 @default.
- W2025801301 cites W2050693842 @default.
- W2025801301 cites W2050720471 @default.
- W2025801301 cites W2052548231 @default.
- W2025801301 cites W2053063855 @default.
- W2025801301 cites W2053401639 @default.
- W2025801301 cites W2058520274 @default.
- W2025801301 cites W2058727371 @default.
- W2025801301 cites W2061579412 @default.
- W2025801301 cites W2064512387 @default.
- W2025801301 cites W2066241876 @default.
- W2025801301 cites W2068075238 @default.
- W2025801301 cites W2069159655 @default.
- W2025801301 cites W2069542459 @default.
- W2025801301 cites W2070967087 @default.
- W2025801301 cites W2073149136 @default.
- W2025801301 cites W2073429282 @default.
- W2025801301 cites W2075495668 @default.
- W2025801301 cites W2076379317 @default.
- W2025801301 cites W2076405456 @default.
- W2025801301 cites W2076782602 @default.
- W2025801301 cites W2077030957 @default.
- W2025801301 cites W2078936452 @default.
- W2025801301 cites W2079434650 @default.
- W2025801301 cites W2079588482 @default.
- W2025801301 cites W2080506742 @default.
- W2025801301 cites W2085201901 @default.
- W2025801301 cites W2086140220 @default.
- W2025801301 cites W2087315272 @default.
- W2025801301 cites W2087551745 @default.
- W2025801301 cites W2088250547 @default.
- W2025801301 cites W2093620447 @default.
- W2025801301 cites W2093718083 @default.
- W2025801301 cites W2094026727 @default.
- W2025801301 cites W2094661084 @default.
- W2025801301 cites W2096000363 @default.
- W2025801301 cites W2096822241 @default.