FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025803464> ?p ?o ?g. }

• W2025803464 endingPage "172" @default.
• W2025803464 startingPage "164" @default.
• W2025803464 abstract "Using a rapid automated enzymatic assay, we prospectively investigated serum D-arabinitol (DA), a biochemical marker of invasive candidiasis, in a large population of high-risk patients to determine its potential diagnostic, therapeutic, and prognostic significance in invasive candidiasis.A total of 3,223 serum samples were collected from 274 patients with cancer. Serum DA concentrations were determined in coded serum samples analyzed by rapid enzymatic assay. Creatinine also was analyzed in the same system to determine a serum DA and creatinine ratio (DA/Cr). The sensitivity, specificity, correlation with therapeutic response, and prognostic significance were analyzed for all patient study groups.A DA/Cr of > or = 4.0 mumol/L per mg/dL was detected in 31 (74%) of all 42 cases of fungemia and 25 (83%) of the 30 cases of the subset of persistent fungemia. Elevated DA/Cr was detected in 4 (40%) of 10 patients with tissue-proven, deeply invasive candidiasis and negative blood cultures (eg, hepatosplenic candidiasis or localized abscess) and 7 (44%) of 16 cases of deep mucosal candidiasis (eg, esophageal candidiasis). Elevated serial DA/Cr levels also were detected in persistently febrile and granulocytopenic patients requiring empirical amphotericin B. Among 26 assessable cases of fungemia, abnormally elevated DA/Cr values were detected in 14 (54%) before, 10 (38%) after, and 2 (8%) simultaneously with the first microbiologic report of fungemia. The trends of serial DA/Cr values correlated with therapeutic response in 29 (85%) of 34 patients with assessable cases of fungemia, decreasing in 8 (89%) of 9 patients with clearance of fungemia and increasing in 21 (84%) of 25 patients with persistence of fungemia. Among the 34 assessable patients with fungemia, mortality was directly related to the trend of serial DA/Cr determinations over time: 71% among fungemic patients who had persistently elevated or increasing DA/Cr, and 18% among the fungemic patients who had resolving DA/Cr or never had elevated DA/Cr (P < 0.01).Rapid enzymatic detection of DA in serially collected serum samples from high-risk cancer patients permitted detection of invasive candidiasis, early recognition of fungemia, and therapeutic monitoring in DA-positive cases. Serially collected serum DA determinations complement blood cultures for improving detection and monitoring therapeutic response in patients at risk for invasive candidiasis." @default.
• W2025803464 created "2016-06-24" @default.
• W2025803464 creator A5001898266 @default.
• W2025803464 creator A5003385068 @default.
• W2025803464 creator A5008809812 @default.
• W2025803464 creator A5015575563 @default.
• W2025803464 creator A5032799576 @default.
• W2025803464 creator A5040164919 @default.
• W2025803464 creator A5041623915 @default.
• W2025803464 creator A5054307799 @default.
• W2025803464 creator A5054425270 @default.
• W2025803464 creator A5060246537 @default.
• W2025803464 creator A5071800632 @default.
• W2025803464 creator A5078392914 @default.
• W2025803464 date "1995-08-01" @default.
• W2025803464 modified "2023-10-03" @default.
• W2025803464 title "Diagnosis and therapeutic monitoring of invasive candidiasis by rapid enzymatic detection of serum d-arabinitol" @default.
• W2025803464 cites W1647373316 @default.
• W2025803464 cites W1785775852 @default.
• W2025803464 cites W1797329289 @default.
• W2025803464 cites W1966548742 @default.
• W2025803464 cites W2007084692 @default.
• W2025803464 cites W2011489112 @default.
• W2025803464 cites W2020942937 @default.
• W2025803464 cites W2022286029 @default.
• W2025803464 cites W2026735415 @default.
• W2025803464 cites W2030622558 @default.
• W2025803464 cites W2031833415 @default.
• W2025803464 cites W2053261047 @default.
• W2025803464 cites W2060684275 @default.
• W2025803464 cites W2069824570 @default.
• W2025803464 cites W2082996726 @default.
• W2025803464 cites W2114208000 @default.
• W2025803464 cites W2135439058 @default.
• W2025803464 cites W2172062003 @default.
• W2025803464 cites W2313875412 @default.
• W2025803464 cites W2327998360 @default.
• W2025803464 cites W2335779668 @default.
• W2025803464 cites W2339375844 @default.
• W2025803464 cites W2341266869 @default.
• W2025803464 cites W3000728709 @default.
• W2025803464 cites W4252230400 @default.
• W2025803464 cites W4300508972 @default.
• W2025803464 doi "https://doi.org/10.1016/s0002-9343(99)80136-3" @default.
• W2025803464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7625421" @default.
• W2025803464 hasPublicationYear "1995" @default.
• W2025803464 type Work @default.
• W2025803464 sameAs 2025803464 @default.
• W2025803464 citedByCount "75" @default.
• W2025803464 countsByYear W20258034642012 @default.
• W2025803464 countsByYear W20258034642015 @default.
• W2025803464 countsByYear W20258034642016 @default.
• W2025803464 countsByYear W20258034642018 @default.
• W2025803464 countsByYear W20258034642019 @default.
• W2025803464 countsByYear W20258034642020 @default.
• W2025803464 countsByYear W20258034642022 @default.
• W2025803464 countsByYear W20258034642023 @default.
• W2025803464 crossrefType "journal-article" @default.
• W2025803464 hasAuthorship W2025803464A5001898266 @default.
• W2025803464 hasAuthorship W2025803464A5003385068 @default.
• W2025803464 hasAuthorship W2025803464A5008809812 @default.
• W2025803464 hasAuthorship W2025803464A5015575563 @default.
• W2025803464 hasAuthorship W2025803464A5032799576 @default.
• W2025803464 hasAuthorship W2025803464A5040164919 @default.
• W2025803464 hasAuthorship W2025803464A5041623915 @default.
• W2025803464 hasAuthorship W2025803464A5054307799 @default.
• W2025803464 hasAuthorship W2025803464A5054425270 @default.
• W2025803464 hasAuthorship W2025803464A5060246537 @default.
• W2025803464 hasAuthorship W2025803464A5071800632 @default.
• W2025803464 hasAuthorship W2025803464A5078392914 @default.
• W2025803464 hasConcept C126322002 @default.
• W2025803464 hasConcept C141071460 @default.
• W2025803464 hasConcept C145081991 @default.
• W2025803464 hasConcept C16005928 @default.
• W2025803464 hasConcept C2779548794 @default.
• W2025803464 hasConcept C2779629538 @default.
• W2025803464 hasConcept C2779959462 @default.
• W2025803464 hasConcept C2780161414 @default.
• W2025803464 hasConcept C2780306776 @default.
• W2025803464 hasConcept C2780558435 @default.
• W2025803464 hasConcept C2780651595 @default.
• W2025803464 hasConcept C2780908437 @default.
• W2025803464 hasConcept C71924100 @default.
• W2025803464 hasConcept C90924648 @default.
• W2025803464 hasConceptScore W2025803464C126322002 @default.
• W2025803464 hasConceptScore W2025803464C141071460 @default.
• W2025803464 hasConceptScore W2025803464C145081991 @default.
• W2025803464 hasConceptScore W2025803464C16005928 @default.
• W2025803464 hasConceptScore W2025803464C2779548794 @default.
• W2025803464 hasConceptScore W2025803464C2779629538 @default.
• W2025803464 hasConceptScore W2025803464C2779959462 @default.
• W2025803464 hasConceptScore W2025803464C2780161414 @default.
• W2025803464 hasConceptScore W2025803464C2780306776 @default.
• W2025803464 hasConceptScore W2025803464C2780558435 @default.
• W2025803464 hasConceptScore W2025803464C2780651595 @default.
• W2025803464 hasConceptScore W2025803464C2780908437 @default.
• W2025803464 hasConceptScore W2025803464C71924100 @default.
• W2025803464 hasConceptScore W2025803464C90924648 @default.

• next