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• W2025809223 startingPage "252" @default.
• W2025809223 abstract "This new approach to immunology engenders a unified conception of embryogenesis, cellular differentiation, mitotic- and growth-control, carcinogenesis, autoimmunity, and aging. The primary and intrinsic function of the complex lymphoid system is postulated to be the central regulation of the growth and size of target tissues throughout the body. Where tissues are normally freely infiltrated by small lymphocytes, these cells, bearing specific mitotic control proteins (MCPs), constitute the effectors of symmetrical mitosis; where target tissues are located behind a blood-tissue barrier, specific humoral MCPs (possibly a2 -macroglobulins) constitute the mitogenic effectors. The protein component of tissue coding factors (TCFs) on cell membranes identifies the target tissue, while the secretion of TCFs from target cells, and their passage to regional lymph nodes via afferent lymphatics, constitutes the afferent signal in the feedback control circuit. Symmetrical mitosis is normally inhibited by the specific contact relations between stem or parent cells of similar differentiation bearing similar TCFs. These views are supported by an analysis of spontaneous disturbed-tolerance autoimmunity. This analysis indicates that the molecular basis of self-recognition is the identity of some or all of the polypeptide chains of lymphoid MCPs and their corresponding target tissue TCFs. London-van der Waal's self-recognition forces account for the specificity of interactions in the central feedback control of symmetrical mitosis. In spontaneous autoimmunity, a special form of gene mutation in lymphoid mitotic control stem cells converts an MCP into a autoantibody (cell-bound or humoral) with a complementary and pathogenic relationship to its associated TCF. The connection between lymphoid MCPs and immunoglobulins is discussed, and a new theory is presented of the classical immune response, and of immunological paralysis." @default.
• W2025809223 created "2016-06-24" @default.
• W2025809223 creator A5031441862 @default.
• W2025809223 creator A5050525528 @default.
• W2025809223 date "1965-09-01" @default.
• W2025809223 modified "2023-09-25" @default.
• W2025809223 title "Self and Not-Self a Clonal Induction Approach to Immunology" @default.
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