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- W2025809865 abstract "The association of rheumatoid arthritis (RA) with a number of genetic risk loci is well established; however, only part of the risk to develop the disease is based on genetics. Environmental factors significantly contribute to the pathogenesis. A gene-environment interaction for smoking and certain major histocompatibility complex (MHC) class II alleles has been shown to promote anti-citrullinated protein antibody (ACPA)-positive RA; however, the molecular mechanisms of interaction remain unclear. In contrast to the genetic background, epigenetic factors are responsive to external stimuli and can modulate gene expression. Therefore, epigenetic mechanisms may function as intermediaries between genetic risk alleles and environmental factors. In this review, epigenetic mechanisms are explained and the evidence for epigenetic changes relevant for the pathogenesis of RA and potential therapeutic applications are discussed." @default.
- W2025809865 created "2016-06-24" @default.
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- W2025809865 date "2014-08-01" @default.
- W2025809865 modified "2023-10-18" @default.
- W2025809865 title "Epigenetic changes: The missing link" @default.
- W2025809865 cites W111560304 @default.
- W2025809865 cites W1501402708 @default.
- W2025809865 cites W1525435670 @default.
- W2025809865 cites W1564492456 @default.
- W2025809865 cites W1579447084 @default.
- W2025809865 cites W1920303762 @default.
- W2025809865 cites W1966024787 @default.
- W2025809865 cites W1971382122 @default.
- W2025809865 cites W1974102799 @default.
- W2025809865 cites W1974976948 @default.
- W2025809865 cites W1978046970 @default.
- W2025809865 cites W1978324852 @default.
- W2025809865 cites W1979206745 @default.
- W2025809865 cites W1985444222 @default.
- W2025809865 cites W1985492450 @default.
- W2025809865 cites W1987557775 @default.
- W2025809865 cites W1988094624 @default.
- W2025809865 cites W1988140132 @default.
- W2025809865 cites W1989211393 @default.
- W2025809865 cites W1996575556 @default.
- W2025809865 cites W1996639668 @default.
- W2025809865 cites W1996826230 @default.
- W2025809865 cites W1998915895 @default.
- W2025809865 cites W2001704867 @default.
- W2025809865 cites W2003877633 @default.
- W2025809865 cites W2008376603 @default.
- W2025809865 cites W2008727668 @default.
- W2025809865 cites W2009423876 @default.
- W2025809865 cites W2010502044 @default.
- W2025809865 cites W2017762858 @default.
- W2025809865 cites W2025252202 @default.
- W2025809865 cites W2025408360 @default.
- W2025809865 cites W2026051181 @default.
- W2025809865 cites W2027393343 @default.
- W2025809865 cites W2028934624 @default.
- W2025809865 cites W2030569291 @default.
- W2025809865 cites W2033366171 @default.
- W2025809865 cites W2033459613 @default.
- W2025809865 cites W2036848594 @default.
- W2025809865 cites W2038824695 @default.
- W2025809865 cites W2043076602 @default.
- W2025809865 cites W2049772720 @default.
- W2025809865 cites W2051806959 @default.
- W2025809865 cites W2053176849 @default.
- W2025809865 cites W2059267677 @default.
- W2025809865 cites W2059695215 @default.
- W2025809865 cites W2062313490 @default.
- W2025809865 cites W2069054327 @default.
- W2025809865 cites W2069208895 @default.
- W2025809865 cites W2084707696 @default.
- W2025809865 cites W2085096810 @default.
- W2025809865 cites W2090789857 @default.
- W2025809865 cites W2091885982 @default.
- W2025809865 cites W2099343472 @default.
- W2025809865 cites W2104451222 @default.
- W2025809865 cites W2107959716 @default.
- W2025809865 cites W2111466507 @default.
- W2025809865 cites W2115593774 @default.
- W2025809865 cites W2117779687 @default.
- W2025809865 cites W2118343231 @default.
- W2025809865 cites W2119308885 @default.
- W2025809865 cites W2119443108 @default.
- W2025809865 cites W2123032740 @default.
- W2025809865 cites W2123257376 @default.
- W2025809865 cites W2127669794 @default.
- W2025809865 cites W2130894316 @default.
- W2025809865 cites W2136131602 @default.
- W2025809865 cites W2136390961 @default.
- W2025809865 cites W2139718273 @default.
- W2025809865 cites W2140102579 @default.
- W2025809865 cites W2140861987 @default.
- W2025809865 cites W2141783531 @default.
- W2025809865 cites W2142745453 @default.
- W2025809865 cites W2147524392 @default.
- W2025809865 cites W2156459401 @default.
- W2025809865 cites W2157916750 @default.
- W2025809865 cites W2160806981 @default.
- W2025809865 cites W2169563954 @default.
- W2025809865 cites W2170688212 @default.
- W2025809865 cites W2170812501 @default.
- W2025809865 cites W2220962109 @default.
- W2025809865 cites W4244629450 @default.
- W2025809865 doi "https://doi.org/10.1016/j.berh.2014.10.014" @default.
- W2025809865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25481551" @default.
- W2025809865 hasPublicationYear "2014" @default.
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