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- W2025819345 abstract "Emphysema is a disease of the lungs that destroys the alveolar air sacs and induces long-term respiratory dysfunction.CT scans allow for the imaging of the anatomical basis of emphysema and quantification of the underlying disease state.Several measures have been introduced for the quantification emphysema directly from CT data; most,however, arebased on the analysis of density information provided by the CT scans, which vary by scanner and can be hard tostandardize across sites and time. Given that one of the anatomical variations associated with the progression ofemphysema is the flatting of the diaphragm due to the loss of elasticity in the lung parenchyma, curvature analysis of thediaphragm would provide information about emphysema from CT. Therefore, we propose a new, non-density basedmeasure of the curvature of the diaphragm that would allow for further quantification methods in a robust manner. Toevaluate the new method, 24 whole-lung scans were analyzed using the ratios of the lung height and diaphragm width todiaphragm height as curvature estimates as well as using the emphysema index as comparison. Pearson correlationcoefficients showed a strong trend of several of the proposed diaphragm curvature measures to have higher correlations,of up to r=0.57, with DLCO% and VA than did the emphysema index. Furthermore, we found emphysema index to haveonly a 0.27 correlation to the proposed measures, indicating that the proposed measures evaluate different aspects of thedisease." @default.
- W2025819345 created "2016-06-24" @default.
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- W2025819345 date "2009-02-26" @default.
- W2025819345 modified "2023-09-23" @default.
- W2025819345 title "Emphysema quantification from CT scans using novel application of diaphragm curvature estimation: comparison with standard quantification methods and pulmonary function data" @default.
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- W2025819345 doi "https://doi.org/10.1117/12.812247" @default.
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