FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025821963> ?p ?o ?g. }

• W2025821963 endingPage "31" @default.
• W2025821963 startingPage "23" @default.
• W2025821963 abstract "Acquired tracheal stenosis is common in patients with a long-term tracheostomy and granulation is one of the most commonly observed lesions in benign airway stenosis. The aim of this study was to investigate the mechanisms of tracheal granulation formation and find the potential therapeutic targets to prevent the granulation formation.In granulation tissue obtained from patients during interventional bronchoscopy for the relief of airway obstruction, increased expression of transforming growth factor (TGF)-β₁ and vascular endothelial growth factor (VEGF), as well as increased numbers of fibroblasts, was found by immunohistochemical staining. TGF-β₁ expression was detected in both the epithelial and submucosal layers. The highest levels of VEGF and vimentin expression occurred in the submucosal layers. In comparison with the control, significantly increased numbers of small vessels were observed in the submucosal layers of the granulation tissue. In vitro, TGF-β₁ stimulated production of VEGF by cultured fibroblasts at both the mRNA and protein level. VEGF siRNA treatment resulted in a significant decrease of TGF-β₁-induced VEGF production. SIS3, a selective Smad3 inhibitor, and UO126 both inhibited p44/42 MAP kinase phosphorylation and attenuated subsequent VEGF production by fibroblasts. A low concentration of erythromycin (1 μg/ml), but not dexamethasone (100 μM), inhibited TGF-β₁-induced VEGF production.This study provides important information that facilitates an understanding, at least in part, of the mechanisms of granulation formation. Targeting these mediators and cells may help to prevent the formation of granulation tissue in long-term tracheostomy or prolonged endotracheal intubation patients." @default.
• W2025821963 created "2016-06-24" @default.
• W2025821963 creator A5000636294 @default.
• W2025821963 creator A5003994290 @default.
• W2025821963 creator A5026200247 @default.
• W2025821963 creator A5050305483 @default.
• W2025821963 creator A5057532204 @default.
• W2025821963 creator A5057534751 @default.
• W2025821963 creator A5057713921 @default.
• W2025821963 creator A5058466826 @default.
• W2025821963 creator A5059211567 @default.
• W2025821963 creator A5059631941 @default.
• W2025821963 creator A5083412953 @default.
• W2025821963 date "2011-02-01" @default.
• W2025821963 modified "2023-10-17" @default.
• W2025821963 title "The roles of transforming growth factor-β₁ and vascular endothelial growth factor in the tracheal granulation formation." @default.
• W2025821963 cites W1965448652 @default.
• W2025821963 cites W1973746369 @default.
• W2025821963 cites W1974955314 @default.
• W2025821963 cites W1983763042 @default.
• W2025821963 cites W1988029636 @default.
• W2025821963 cites W1994738588 @default.
• W2025821963 cites W2014077602 @default.
• W2025821963 cites W2018610943 @default.
• W2025821963 cites W2037620883 @default.
• W2025821963 cites W2038408489 @default.
• W2025821963 cites W2048301069 @default.
• W2025821963 cites W2056051088 @default.
• W2025821963 cites W2059888335 @default.
• W2025821963 cites W2074238578 @default.
• W2025821963 cites W2080761559 @default.
• W2025821963 cites W2090898517 @default.
• W2025821963 cites W2095512229 @default.
• W2025821963 cites W2122808924 @default.
• W2025821963 cites W2145007867 @default.
• W2025821963 cites W2152733931 @default.
• W2025821963 cites W2153646508 @default.
• W2025821963 cites W2161064750 @default.
• W2025821963 cites W2162291597 @default.
• W2025821963 cites W2163987761 @default.
• W2025821963 cites W2164094961 @default.
• W2025821963 cites W2164800412 @default.
• W2025821963 cites W2168003760 @default.
• W2025821963 cites W2316067769 @default.
• W2025821963 cites W2752459639 @default.
• W2025821963 cites W4240441625 @default.
• W2025821963 doi "https://doi.org/10.1016/j.pupt.2010.10.016" @default.
• W2025821963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21056681" @default.
• W2025821963 hasPublicationYear "2011" @default.
• W2025821963 type Work @default.
• W2025821963 sameAs 2025821963 @default.
• W2025821963 citedByCount "21" @default.
• W2025821963 countsByYear W20258219632012 @default.
• W2025821963 countsByYear W20258219632013 @default.
• W2025821963 countsByYear W20258219632014 @default.
• W2025821963 countsByYear W20258219632016 @default.
• W2025821963 countsByYear W20258219632017 @default.
• W2025821963 countsByYear W20258219632018 @default.
• W2025821963 countsByYear W20258219632019 @default.
• W2025821963 countsByYear W20258219632020 @default.
• W2025821963 countsByYear W20258219632021 @default.
• W2025821963 countsByYear W20258219632022 @default.
• W2025821963 countsByYear W20258219632023 @default.
• W2025821963 crossrefType "journal-article" @default.
• W2025821963 hasAuthorship W2025821963A5000636294 @default.
• W2025821963 hasAuthorship W2025821963A5003994290 @default.
• W2025821963 hasAuthorship W2025821963A5026200247 @default.
• W2025821963 hasAuthorship W2025821963A5050305483 @default.
• W2025821963 hasAuthorship W2025821963A5057532204 @default.
• W2025821963 hasAuthorship W2025821963A5057534751 @default.
• W2025821963 hasAuthorship W2025821963A5057713921 @default.
• W2025821963 hasAuthorship W2025821963A5058466826 @default.
• W2025821963 hasAuthorship W2025821963A5059211567 @default.
• W2025821963 hasAuthorship W2025821963A5059631941 @default.
• W2025821963 hasAuthorship W2025821963A5083412953 @default.
• W2025821963 hasConcept C105922876 @default.
• W2025821963 hasConcept C118131993 @default.
• W2025821963 hasConcept C126322002 @default.
• W2025821963 hasConcept C141071460 @default.
• W2025821963 hasConcept C142724271 @default.
• W2025821963 hasConcept C146285616 @default.
• W2025821963 hasConcept C147447768 @default.
• W2025821963 hasConcept C159985019 @default.
• W2025821963 hasConcept C167734588 @default.
• W2025821963 hasConcept C170493617 @default.
• W2025821963 hasConcept C185592680 @default.
• W2025821963 hasConcept C192562407 @default.
• W2025821963 hasConcept C203014093 @default.
• W2025821963 hasConcept C204232928 @default.
• W2025821963 hasConcept C2775960820 @default.
• W2025821963 hasConcept C2776055305 @default.
• W2025821963 hasConcept C2777025900 @default.
• W2025821963 hasConcept C2780269544 @default.
• W2025821963 hasConcept C2908550248 @default.
• W2025821963 hasConcept C502942594 @default.
• W2025821963 hasConcept C71924100 @default.
• W2025821963 hasConcept C88463166 @default.
• W2025821963 hasConceptScore W2025821963C105922876 @default.

• next