FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025828310> ?p ?o ?g. }

• W2025828310 endingPage "70" @default.
• W2025828310 startingPage "65" @default.
• W2025828310 abstract "Lymphocyte function associate-1 (LFA-1), macrophage antigen-1 (Mac-1), and very late activation antigen-4 (VLA-4) are involved in the infiltration of leukocytes into the tissues. Experimental models of allergic inflammation suggest that VLA-4 could determine the selective recruitment of eosinophils into the inflamed airways.Our purpose was to evaluate the involvement of integrins in eosinophil recruitment in asthma.We evaluated by immunocytochemistry the expression of VLA-4, LFA-1, and Mac-1 and their relationship with inflammatory cells and severity of disease in the induced sputum of 20 mild to moderate atopic asthmatic subjects and in 8 healthy subjects.The number of VLA-4+ cells is increased in asthmatic patients and VLA-4 is mainly localized on eosinophils. Furthermore, VLA-4+ cells are significantly related to eosinophils. In contrast, LFA-1 and Mac-1 cellular expressions do not differ between asthmatic and control subjects and are not related to any specific cell type. Eosinophils and VLA-4+ cells are significantly higher in moderately compared with mildly asthmatic patients (P <.01, P <.05) and with healthy control subjects (P <.0005, P <.001). Eosinophils and VLA-4+ cells are also higher in mildly asthmatic patients compared with control subjects (P <.001, P <.005).This is the first report demonstrating, by a noninvasive method in humans, that VLA-4+ cells are increased and correlate with the eosinophils in the induced sputum of atopic patients with mild to moderate asthma and that VLA-4 expression is related to the severity of disease." @default.
• W2025828310 created "2016-06-24" @default.
• W2025828310 creator A5004081003 @default.
• W2025828310 creator A5026732096 @default.
• W2025828310 creator A5038906869 @default.
• W2025828310 creator A5044845582 @default.
• W2025828310 creator A5051363118 @default.
• W2025828310 creator A5074837597 @default.
• W2025828310 creator A5081416826 @default.
• W2025828310 creator A5085703122 @default.
• W2025828310 creator A5086352694 @default.
• W2025828310 date "2000-01-01" @default.
• W2025828310 modified "2023-10-16" @default.
• W2025828310 title "The increased number of very late activation antigen-4–positive cells correlates with eosinophils and severity of disease in the induced sputum of asthmatic patients" @default.
• W2025828310 cites W1997453039 @default.
• W2025828310 cites W1997794457 @default.
• W2025828310 cites W2008093400 @default.
• W2025828310 cites W2027187981 @default.
• W2025828310 cites W2030278924 @default.
• W2025828310 cites W2036267690 @default.
• W2025828310 cites W2049133041 @default.
• W2025828310 cites W2059242779 @default.
• W2025828310 cites W2059336940 @default.
• W2025828310 cites W2089740140 @default.
• W2025828310 cites W2099671967 @default.
• W2025828310 cites W2110366281 @default.
• W2025828310 cites W2130191659 @default.
• W2025828310 cites W2138556841 @default.
• W2025828310 cites W2141575089 @default.
• W2025828310 cites W2147532546 @default.
• W2025828310 cites W2167196294 @default.
• W2025828310 cites W2187350285 @default.
• W2025828310 cites W376589566 @default.
• W2025828310 cites W4239185404 @default.
• W2025828310 doi "https://doi.org/10.1016/s0091-6749(00)90179-9" @default.
• W2025828310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10629454" @default.
• W2025828310 hasPublicationYear "2000" @default.
• W2025828310 type Work @default.
• W2025828310 sameAs 2025828310 @default.
• W2025828310 citedByCount "22" @default.
• W2025828310 countsByYear W20258283102012 @default.
• W2025828310 countsByYear W20258283102015 @default.
• W2025828310 countsByYear W20258283102020 @default.
• W2025828310 countsByYear W20258283102023 @default.
• W2025828310 crossrefType "journal-article" @default.
• W2025828310 hasAuthorship W2025828310A5004081003 @default.
• W2025828310 hasAuthorship W2025828310A5026732096 @default.
• W2025828310 hasAuthorship W2025828310A5038906869 @default.
• W2025828310 hasAuthorship W2025828310A5044845582 @default.
• W2025828310 hasAuthorship W2025828310A5051363118 @default.
• W2025828310 hasAuthorship W2025828310A5074837597 @default.
• W2025828310 hasAuthorship W2025828310A5081416826 @default.
• W2025828310 hasAuthorship W2025828310A5085703122 @default.
• W2025828310 hasAuthorship W2025828310A5086352694 @default.
• W2025828310 hasConcept C126322002 @default.
• W2025828310 hasConcept C142724271 @default.
• W2025828310 hasConcept C147483822 @default.
• W2025828310 hasConcept C203014093 @default.
• W2025828310 hasConcept C207480886 @default.
• W2025828310 hasConcept C2776042228 @default.
• W2025828310 hasConcept C2776301714 @default.
• W2025828310 hasConcept C2776914184 @default.
• W2025828310 hasConcept C2777037409 @default.
• W2025828310 hasConcept C2777761686 @default.
• W2025828310 hasConcept C2778593620 @default.
• W2025828310 hasConcept C2779675166 @default.
• W2025828310 hasConcept C2781069245 @default.
• W2025828310 hasConcept C2909375385 @default.
• W2025828310 hasConcept C35866371 @default.
• W2025828310 hasConcept C71924100 @default.
• W2025828310 hasConceptScore W2025828310C126322002 @default.
• W2025828310 hasConceptScore W2025828310C142724271 @default.
• W2025828310 hasConceptScore W2025828310C147483822 @default.
• W2025828310 hasConceptScore W2025828310C203014093 @default.
• W2025828310 hasConceptScore W2025828310C207480886 @default.
• W2025828310 hasConceptScore W2025828310C2776042228 @default.
• W2025828310 hasConceptScore W2025828310C2776301714 @default.
• W2025828310 hasConceptScore W2025828310C2776914184 @default.
• W2025828310 hasConceptScore W2025828310C2777037409 @default.
• W2025828310 hasConceptScore W2025828310C2777761686 @default.
• W2025828310 hasConceptScore W2025828310C2778593620 @default.
• W2025828310 hasConceptScore W2025828310C2779675166 @default.
• W2025828310 hasConceptScore W2025828310C2781069245 @default.
• W2025828310 hasConceptScore W2025828310C2909375385 @default.
• W2025828310 hasConceptScore W2025828310C35866371 @default.
• W2025828310 hasConceptScore W2025828310C71924100 @default.
• W2025828310 hasIssue "1" @default.
• W2025828310 hasLocation W20258283101 @default.
• W2025828310 hasLocation W20258283102 @default.
• W2025828310 hasOpenAccess W2025828310 @default.
• W2025828310 hasPrimaryLocation W20258283101 @default.
• W2025828310 hasRelatedWork W1493798642 @default.
• W2025828310 hasRelatedWork W1967351750 @default.
• W2025828310 hasRelatedWork W1979377340 @default.
• W2025828310 hasRelatedWork W2051954172 @default.
• W2025828310 hasRelatedWork W2066810707 @default.
• W2025828310 hasRelatedWork W2109032237 @default.
• W2025828310 hasRelatedWork W2126681179 @default.

• next